Table 2.
Baseline imaging measures for the Healthy Volunteer sample in the pilot phase.
| Region | Measurement | Mean ± SD |
|---|---|---|
| Left pSTC | GABA/Cre Concentration (mmol/L) | 0.54 ± 0.05 (n=10) |
| Glutamate/Cre Concentration (mmol/L) | 1.25 ± 0.13 (n=10) | |
| Left Heschl’s Gyrus | Evoked Gamma Power | 0.32 ± 0.38 (n=13) |
| M100 Latency (ms) | 98.4 ± 9.9 (n=10) | |
| Right Heschl’s Gyrus | Evoked Gamma Power | 0.48 ± 0.36 (n=13) |
| M100 Latency (ms) | 97.6 ± 7.7 (n=9) | |
| Left Arcuate Fasciculus | FA | 0.45 ± 0.01 (n=19) |
| MD | 0.76 ± 0.01 (n=19) | |
| RD | 0.55 ± 0.02 (n=19) | |
| AD | 1.14 ± 0.02 (n=19) | |
| Right Arcuate Fasciculus | FA | 0.45 ± 0.02 (n=19) |
| MD | 0.75 ± 0.04 (n=19) | |
| RD | 0.55 ± 0.02 (n=19) | |
| AD | 1.13 ± 0.02 (n=19) | |
| Left Auditory Radiations | FA | 0.39 ± 0.01 (n=19) |
| MD | 0.89 ± 0.04 (n=19) | |
| RD | 0.71 ± 0.04 (n=19) | |
| AD | 1.26 ± 0.04 (n=19) | |
| Right Auditory Radiations | FA | 0.39 ± 0.02 (n=19) |
| MD | 0.88 ± 0.02 (n=19) | |
| RD | 0.70 ± 0.03 (n=19) | |
| AD | 1.24 ± 0.03 (n=19) |
GABA and Glutamate concentrations are measured over creatine. The MRS voxel was centered on the individualized cTBS target as defined by the peak bold activation to the ADDT task. Voxels were 2.5 cm cubed, thus the value represents relative concentrations of metabolites within the posterior superior temporal cortex.
Mean and standard deviation values for Evoked Gamma Power and FA are dimensionless.
Mean and standard deviation values for MD, RD, and AD are measured in 10-3 mm2/s.
Sample sizes varied based on data quality and visit completion.
FA, Fractional Anisotropy; MD, Mean Diffusivity; RD, Radial Diffusivity; AD, Axial Diffusivity.