Figure 4.

Direct and indirect MYC-targeted therapeutic strategies. Therapeutic inhibitors are depicted as labeled red boxes. PC585 inhibits CDK9, JQ1 inhibits BRD4, and THZ-1 inhibits CDK4, which together are key transcription factors that regulate MYC gene expression. BEZ235 is a PI3K inhibitor, MK2206 is an Akt inhibitor, and Rapamycin is a mTOR inhibitor, which together inhibit the translation of MYC. 10074-G5, 10058-F4, Omomyc, and Mycro3 inhibits the heterodimerization of MYC and MAX. Entinostat inhibits HAT and 5’azacytidine inhibits DNMT which are co-factors that aid in MYC activated transcription of gene targets. FX11 inhibits LDHA, a gene target of MYC, and thus inhibits the downstream function of MYC activation. Created with BioRender.com.