Fig. 3.

Association analysis of HF1 haplotypes. A set of the eight most informative SNPs in the HF1 gene were selected and analyzed for pairwise linkage disequilibrium in the Columbia cases and controls. R2 and D′ values are shown. All of the haplotypes with a frequency of >3% are displayed. The ORs for the comparison of cases and controls were calculated, and 95% CIs are shown in brackets. The estimated frequencies of the haplotype in cases (CAS) and controls (CON) are also shown. The major risk haplotype (H1) is shown in dark shading, and the protective haplotypes are shown in light shading. SNPs exclusively found in these risk and protective haplotypes are boxed. Analysis of diplotypes was performed to assess dominant and recessive effects. Homozygotes for the H1 haplotype (H1/H1) are significantly at risk, and H2/H2 individuals are significantly protected. Detailed information pertaining to analyses and access to additional data is provided in Supporting Text: Statistical Analyses.