TABLE 2.

Key parameters in different manufacturing techniques of HMPs.

Manufacturing techniques	Particle size distribution (μm)	Particle production rate	Cell compatibility during particle fabrication	Ref.
Microfluidic emulsion	5–10	Average	Average (>80% viability)	Pittermannová et al. (2016), Headen et al. (2018), Zhang et al. (2018)
Batch emulsion	1–10	High	Average (>80% viability)	Franco et al. (2011), Leong et al. (2013)
EHD sputtering	1–10	Average	Average (>80% viability)	Naqvi et al. (2016), Qayyum et al. (2017), Gansau et al. (2018)
Mechanical fragmentation	20–50	High	_	Sinclair et al. (2018)
Lithography	<1 possible	Low	High (>90%)	Pregibon et al. (2007), Le Goff et al. (2015)