Respiratory syncytial virus (RSV) is a highly contagious virus that is a recognized global health concern; however, our understanding of the burden of RSV in Latin America is limited, particularly among older adults and those with underlying health conditions.

In light of this, we provide an overview of the available data on RSV in Latin America, highlight significant epidemiological challenges, and propose an expert consensus on the efforts needed to improve our understanding of RSV and alleviate its burden in the region.

Overall, we found a substantial lack of epidemiological data on RSV in Latin America and discuss its potential underestimated prevalence due to underdiagnosis and limited surveillance, as well as its considerable impact in older adults and those with comorbidities, on the basis of insights from other regions.

Considering these findings, we advocate for routine testing of RSV, medical education initiatives to inform clinicians on RSV in older adults, and the development of a surveillance taskforce to accurately monitor the burden of RSV in Latin America.