Table 1.
Overview of molecular quantitative trait loci (QTL) summary statistics employed in this work.
| Tissue/cell type | QTL type | Sample size | Reference |
|---|---|---|---|
| Cortex Europeans | Expression | 2683 | MetaBrain95 |
| Cortex East Asians | Expression | 208 | MetaBrain95 |
| Cortex Africans | Expression | 319 | MetaBrain95 |
| Basal ganglia | Expression | 208 | MetaBrain95 |
| Hippocampus | Expression | 168 | MetaBrain95 |
| Cerebellum | Expression | 492 | MetaBrain95 |
| Brain (prefrontal cortex)* | Chromatin accessibility | 292 | PsychENCODE51 |
| Brain (prefrontal cortex) | Protein | 330 | PsychENCODE51 |
| Brain (dorsolateral prefrontal cortex) | Methylation | 411 | Ng et al.96 |
| Brain amygdala | Splicing | 129 | GTEx v897 |
| Brain cerebellum | Splicing | 209 | GTEx v897 |
| Brain cortex | Splicing | 205 | GTEx v897 |
| Brain frontal cortex | Splicing | 175 | GTEx v897 |
| Brain hippocampus | Splicing | 165 | GTEx v897 |
| Brain hypothalamus | Splicing | 170 | GTEx v897 |
| Brain amygdala | Expression | 129 | GTEx v897 |
| Brain hypothalamus | Expression | 170 | GTEx v897 |
| Brain cells (single cell data) | Expression | 192 | Bryois et al.98 |
| Fetal brain (prefrontal cortex, striatum and cerebellum)* | Methylation | 166 | Hannon et al.99 |
| Fetal brain (no specific region) | Expression | 120 | O’Brien et al.100 |
| Pancreatic islets | Expression | 420 | InsPIRE101 |
| Pancreatic islets* | Splicing | 399 | Atla et al.102 |
| Liver | Expression | 208 | GTEx v897 |
| Liver* | Protein | 287 | He et al.103. |
| Liver | Splicing | 208 | GTEx v897 |
| Subcutaneous adipose tissue | Expression | 581 | GTEx v897 |
| Subcutaneous adipose tissue | Expression | 434 | METSIM54 |
| Subcutaneous adipose tissue | Splicing | 426 | METSIM104 |
| Subcutaneous adipose tissue | Splicing | 581 | GTEx v897 |
| Visceral adipose tissue | Expression | 469 | GTEx v897 |
| Visceral adipose tissue | Splicing | 469 | GTEx v897 |