Figure 2.

Effects of inverse folding and bagging. Ablation results on the validation set of AlphaFold predicted structures, with less than 50% sequence similarity to the training set. The plot reports the AUC-ROC for a single XGboost model trained on representations based on ESM-2 650M parameter (blue) and on ESM-IF1 (orange), for an ensemble of 20 XGboost models based on bootstraps of ESM-IF1 representations (purple), for models where additional structural features are included (see Methods) tested on both AlphaFold models (green) and on the corresponding solved structures (red) (see Methods). Error bars indicate 95% confidence interval.