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. 2024 Feb 8;15:1322712. doi: 10.3389/fimmu.2024.1322712

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Copyright © 2024 Høie, Gade, Johansen, Würtzen, Winther, Nielsen and Marcatili

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DiscoTope-3.0 score significantly correlates with antibody hit rate. Lysozyme epitope propensity as predicted by DiscoTope-3.0, excluding all lysozyme antigens from training. (A) PDB antibody hit rate mapped AlphaFold predicted structure (chain 1a2y_C), with increasing epitope propensity shown in red. (B) DiscoTope-3.0 score. (C) Epitope propensity visualized across the antigen sequence. Calibrated DiscoTope-3.0 score and antibody hit rate (epitope counts) shown, as measured from aligning the 12 epitope mapped lysozyme sequences (Spearman R = 0.58). Additional performance metrics available in Table 2 .