Table 2.
Performance on benchmarking datasets.
| Metric | Dataset | ||
|---|---|---|---|
| Lysozyme (AlphaFold) |
External test set (AlphaFold) |
External test set (Solved) |
|
| AUC-PR | 0.722 | 0.232 | 0.223 |
| AUC-ROC | 0.809 | 0.783 | 0.795 |
| MCC | 0.521 | 0.227 | 0.214 |
| Total residues | 129 | 6788 | 6788 |
| Observed epitope residues | 55 (223 before collapsing) | 436 | 436 |
| # antigen structures | 1 (12 before collapsing) | 24 | 24 |
Overview of external test set and lysozyme test sets for solved and AlphaFold predicted antigens. Matthew correlation coefficient (MCC) calculated at optimal sensitivity-specificity threshold using the Youden-index.