Table 4.
Glucagon alters insulin clearance
| Period | Saline (n = 8) | P vs. baseline (within saline) | Clamp (n = 9) | P vs. baseline (within clamp) | P vs. saline (within period) | |
|---|---|---|---|---|---|---|
| C-peptide:insulin ratio | Fasting | 9.5 ± 1.0 | 0.7442 | 10.1 ± 1.1 | 0.0163 | 0.5406 |
| Baseline | 9.9 ± 0.9 | — | 7.3 ± 0.8 | — | 0.0025 | |
| Glucagon | 4.0 ± 0.5 | <0.0001 | 2.8 ± 0.4 | <0.0001 | <0.0001 | |
| MCRi | Fasting | 0.58 ± 0.05 | 0.9918 | 0.60 ± 0.05 | 0.7399 | 0.8489 |
| Baseline | 0.59 ± 0.05 | — | 0.53 ± 0.05 | — | 0.5217 | |
| Glucagon | 0.44 ± 0.05 | 0.1902 | 0.27 ± 0.05 | 0.0006 | 0.003 | |
| Insulin t1/2 (min) | Fasting | 2.8 ± 0.9 | 0.8999 | 2.6 ± 0.8 | 0.7479 | 0.8852 |
| Baseline | 2.5 ± 0.9 | — | 3.0 ± 0.8 | — | 0.3265 | |
| Glucagon | 7.9 ± 0.9 | 0.0008 | 7.4 ± 0.8 | 0.0021 | 0.8384 |
Data are least squares means ± SEM. P values are from Tukey-adjusted post hoc comparisons. Average C-peptide:insulin ratios, MCRi, and insulin t1/2 are reported for the fasting, baseline, and glucagon periods.