Table 1.
Key patient baseline demographic and clinical characteristics of the primary population
| Tafenoquine (n=2685) |
Primaquine |
No tafenoquine or primaquine (n=113) | |||||
|---|---|---|---|---|---|---|---|
| 7-day (n=2631) | 14-day (n=257) | Weekly (n=340) | All (n=3228) | ||||
| Municipality | |||||||
| Manaus | 921 (34·3%) | 707 (26·9%) | 53 (20·6%) | 113 (33·2%) | 873 (27·0%) | 46 (40·7%) | |
| Porto Velho | 1764 (65·7%) | 1924 (73·1%) | 204 (79·4%) | 227 (66·8%) | 2355 (73·0%) | 67 (59·3%) | |
| Age, years | 39·8 (14·0) | 33·2 (17·7) | 35·4 (16·4) | 34·8 (16·6) | 33·5 (17·5) | 28·1 (12·6) | |
| Sex | |||||||
| Male | 1783 (66·4%) | 1705 (64·8%) | 170 (66·1%) | 220 (64·7%) | 2095 (64·9%) | 36 (31·9%) | |
| Female | 902 (33·6%) | 926 (35·2%) | 87 (33·9%) | 120 (35·3%) | 1133 (35·1%) | 77 (68·1%) | |
| Childbearing potential* | 658 (72·9%) | 506 (54·6%) | 53 (60·9%) | 78 (65·0%) | 637 (56·2%) | 67 (87·0%) | |
| Breastfeeding† | |||||||
| Yes | 6 (0·9%) | 54 (10·7%) | 2 (3·8%) | 7 (9·0%) | 63 (9·9%) | 7 (10·4%) | |
| No | 617 (93·8%) | 416 (82·2%) | 44 (83·0%) | 67 (85·9%) | 527 (82·7%) | 54 (80·6%) | |
| Missing | 35 (5·3%) | 36 (7·1%) | 7 (13·2%) | 4 (5·1%) | 47 (7·4%) | 6 (9·0%) | |
| Pregnant† | |||||||
| Yes | 0 | 0 | 0 | 0 | 0 | 49 (73·1%)‡ | |
| No | 658 (100·0%) | 506 (100·0%) | 53 (100·0%) | 78 (100·0%) | 637 (100·0%) | 20 (29·9%) | |
| Ethnicity | |||||||
| Mixed | 2275 (84·7%) | 2208 (83·9%) | 211 (82·1%) | 292 (85·9%) | 2711 (84·0%) | 95 (84·1%) | |
| White | 275 (10·2%) | 293 (11·1%) | 29 (11·3%) | 35 (10·3%) | 357 (11·1%) | 13 (11·5%) | |
| Black | 93 (3·5%) | 88 (3·3%) | 11 (4·3%) | 8 (2·4%) | 107 (3·3%) | 2 (1·8%) | |
| Indigenous | 25 (0·9%) | 28 (1·1%) | 5 (1·9%) | 3 (0·9%) | 36 (1·1%) | 1 (0·9%) | |
| Asian | 17 (0·6%) | 14 (0·5%) | 1 (0·4%) | 2 (0·6%) | 17 (0·5%) | 2 (1·8%) | |
Data are n (%) or mean (SD). Additional baseline data are included in the appendix (p 2).
*
Denominator for percentage is the number of female participants.
†
Denominator for percentage is the number of female participants of childbearing potential (defined as age ≥16 to <50 years).
‡
Includes two patients younger than 16 years.