Table 3.
Characteristics of all patients receiving tafenoquine by facility level and type of facility and overall
|
Higher-level and medium-level facilities |
Lower-level facilities |
Overall (n=2685) | ||||||
|---|---|---|---|---|---|---|---|---|
| Hospitals (n=520) | Emergency care (n=1783) | All (n=2303) | Basic health unit (n=270) | Operational base (n=112) | All (n=382) | |||
| Treatment algorithm* | ||||||||
| Correct | 508 (97·7% [96·0–98·8]) | 1750 (98·1% [97·4–98·7]) | 2258 (98·0% [97·4–98·6]) | 254 (94·1% [90·6–96·6]) | 111 (99·1% [95·1–100]) | 365 (95·5% [93·0–97·4]) | 2623 (97·7% [97·0–98·2]) | |
| Incorrect | 12 (2·3%) | 33 (1·9%) | 45 (2·0%) | 16 (5·9%) | 1 (0·9%) | 17 (4·5%) | 62 (2·3%) | |
| G6PD activity† | ||||||||
| Correct | 519 (99·8% [98·9–100]) | 1771 (99·3% [98·8–99·7]) | 2290 (99·4% [99·0–99·7]) | 267 (98·9% [96·8–99·8]) | 112 (100% [96·8–100]) | 379 (99·2% [97·7–99·8]) | 2669 (99·4% [99·0–99·7]) | |
| Incorrect | 1 (0·2%) | 12 (0·7%) | 13 (0·6%) | 3 (1·1%) | 0 | 3 (0·8%) | 16 (0·6%) | |
| Age‡ | ||||||||
| Correct | 520 (100% [99·3–100]) | 1778 (99·7% [99·3–99·9]) | 2298 (99·8% [99·5–99·9]) | 270 (100% [98·6–100]) | 112 (100% [96·8–100]) | 382 (100% [99·0–100]) | 2680 (99·8% [99·6–99·9]) | |
| Incorrect | 0 | 5 (0·3%) | 5 (0·2%) | 0 | 0 | 0 | 5 (0·2%) | |
| Female participants of childbearing potential§ | 137 | 421 | 558 | 70 | 30 | 100 | 658 | |
| Non-breastfeeding | 126 (92·0% [86·1–95·9]) | 405 (96·2% [93·9–97·8]) | 531 (95·2% [93·0–96·8]) | 57 (81·4% [70·3–89·4]) | 29 (96·7% [82·8–99·9]) | 86 (86·0% [77·6–92·1]) | 617 (93·8% [91·6–95·5]) | |
| Breastfeeding | 1 (0·7%) | 3 (0·7%) | 4 (0·7%) | 2 (2·9%) | 0 | 2 (2·0%) | 6 (0·9%) | |
| Breastfeeding unknown | 10 (7·3%) | 13 (3·1%) | 23 (4·1%) | 11 (15·7%) | 1 (3·3%) | 12 (12·0%) | 35 (5·3%) | |
| Non-pregnant | 137 (100% [97·3–100]) | 421 (100% [99·1–100]) | 558 (100% [99·3–100]) | 70 (100% [94·9–100]) | 30 (100% [88·4–100]) | 100 (100% [96·4–100]) | 658 (100% [99·4–100]) | |
| Pregnant | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
Data are n, n (%), or n (% [95% CI]). G6PD=glucose-6-phosphate dehydrogenase.
*
Based on normal G6PD activity (≥6·1 U/g Hb), in participants aged at least 16 years, non-breastfeeding, and non-pregnant.
†
Based on normal G6PD activity (≥6·1 U/g Hb).
‡
Based on participants aged at least 16 years.
§
Based on female patients aged at least 16 years to younger than 50 years.