Table 1.

Global average AAPC in incidence, prevalence and YLDs of bipolar disorders

Sex	Years	Incidence		Prevalence		YLDs
		AAPC (95% CI)	P value	AAPC (95% CI)	P value	AAPC (95% CI)	P value
All	1990–1999	0.34 (0.30 to 0.37)	<0.001	0.11 (0.10 to 0.13)	<0.001	0.12 (0.10 to 0.13)	<0.001
	2000–2009	0.06 (0.05 to 0.06)	<0.001	0.38 (0.37 to 0.39)	<0.001	0.39 (0.38 to 0.40)	<0.001
	2010–2019	0.38 (0.33 to 0.43)	<0.001	0.15 (0.14 to 0.16)	<0.001	0.15 (0.14 to 0.17)	<0.001
	1990–2019	0.24 (0.22 to 0.26)	<0.001	0.21 (0.20 to 0.21)	<0.001	0.21 (0.20 to 0.22)	<0.001
Female	1990–1999	0.32 (0.30 to 0.34)	<0.001	0.13 (0.11 to 0.14)	<0.001	0.13 (0.11 to 0.15)	<0.001
	2000–2009	0.03 (0.03 to 0.04)	<0.001	0.34 (0.33 to 0.34)	<0.001	0.34 (0.33 to 0.36)	<0.001
	2010–2019	0.37 (0.35 to 0.38)	<0.001	0.11 (0.10 to 0.12)	<0.001	0.11 (0.10 to 0.13)	<0.001
	1990–2019	0.23 (0.22 to 0.24)	<0.001	0.18 (0.18 to 0.19)	<0.001	0.19 (0.18 to 0.20)	<0.001
Male	1990–1999	0.35 (0.33 to 0.36)	<0.001	0.10 (0.09 to 0.12)	<0.001	0.10 (0.08 to 0.13)	<0.001
	2000–2009	0.08 (0.06 to 0.10)	<0.001	0.43 (0.41 to 0.44)	<0.001	0.44 (0.42 to 0.46)	<0.001
	2010–2019	0.39 (0.38 to 0.40)	<0.001	0.19 (0.17 to 0.20)	<0.001	0.19 (0.17 to 0.21)	<0.001
	1990–2019	0.26 (0.25 to 0.27)	<0.001	0.23 (0.22 to 0.24)	<0.001	0.24 (0.23 to 0.25)	<0.001

AAPC, average annual percentage change; CI, confidence interval; YLDs, years lived with disability.