Fig. 6. Humoral response of single dose μ-OVA@ZIF vs. OVA 3×. (A) Scheme of vaccine and blood draw schedule for determining endpoint titers of anti-OVA IgG. (B) Endpoint titers of Anti-OVA IgG from mouse serum. IFN-γ concentration (pg mL−1) in mouse serum following vaccination on (C) day 7 and (D) day 14 determined through ELISA. (E) Day 21 GC formation in the ILN of vaccinated mice. (F) Percentage of IgG1+ GC B cells in the ILN. Statistical significance was determined by an unpaired Student's t-test (P > 0.05 is ns, P ≤ 0.05 is *, P ≤ 0.01 is **, P ≤ 0.001 is ***, and P ≤ 0.0001 is ****).
