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. 2024 Feb 21;28:56. doi: 10.1186/s13054-024-04819-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Change in log10 biomarker concentration over time by subtype assignment in the control arm (N = 142). A Biomarkers of inflammation, B endothelial injury, C alveolar epithelial injury, and D disordered coagulation. Y-axis is the log10 concentration of biomarker. Estimates with 95% confidence intervals derived from linear mixed effects models. Asterisks denote significant difference in the slope of biomarker change over time between Subtype 1 and Subtype 2 based on Chi-squared test of interaction. *p value < 0.05. **p value < 0.005. ***p value < 0.001