Table 2.
Association Between Psychological Distress Score Tertiles and the Study Endpoint (an Aggregate of Cardiovascular Death or First or Recurrent Nonfatal Myocardial Infarction or Heart Failure Hospitalization), in Each Cohort
| Tertile 1 (Low Psychological Distress) | Tertile 2 (Moderate Psychological Distress) | Tertile 3 (Severe Psychological Distress) | |
|---|---|---|---|
| MIPS cohort | |||
| Model 1 | Ref | 0.98 (0.57-1.68) | 1.68(1.16-2.43) |
| Model 2 | Ref | 0.95 (0.55-1.63) | 1.50(1.07-2.29) |
| Model 3 | Ref | 0.94 (0.55-1.63) | 1.47(1.06-2.23) |
| MIMS2 cohort | |||
| Model 1 | Ref | 2.80(1.22-6.43) | 3.65(1.77-7.52) |
| Model 2 | Ref | 2.65(1.11-6.29) | 3.30(1.58-6.92) |
| Model 3 | Ref | 2.19(1.06-4.99) | 2.38(1.11-5.07) |
Values are HR (95% CI). Model 1: Unadjusted.
Model 2: Adjusted for age, sex, race (Black vs non-Black), and family income.
Model 3: Adjusted for Model 2 variables plus clinical risk factors, including body mass index, ever smoking, history of hypertension, hyperlipidemia, diabetes mellitus, prior myocardial infarction, prior revascularization, and heart failure. Bold values are statistically significant at P < 0.05.
MIMS2 = Myocardial Infarction and Mental Stress Study 2; MIPS = Mental Stress Ischemia Prognosis Study.