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. 2024 Feb 21;15(1):2314297. doi: 10.1080/19491034.2024.2314297

Figure 1.

Panel A: A table listing the Nups contained within each subdomain of the Nuclear Pore Complex, including cytoplasmic filaments, the coat nucleoporin complex, the inner ring, the central channel, transmembrane Nups, and the nuclear basket. Panel B: A cartoon diagram of a Nuclear Pore Complex within the nuclear envelope.

The nuclear pore complex is a large macromolecular structure. (a) The nuclear pore complex (NPC) is comprised of six subdomains: the cytoplasmic filaments, the coat nucleoporin complex, the inner ring, the central channel, the transmembrane nucleoporins, and the nuclear basket. Many phenylalanine-glycine (FG)-Nups (indicated by an asterisk) are found in the central channel. However, FG-Nups are also found at the asymmetric cytoplasmic and nuclear faces of the NPC. (b) The NPC sits within the double membrane of the nucleus, and the NPC core demonstrates two-fold symmetry across the nuclear envelope, with the asymmetric cytoplasmic filaments and nuclear basket Nups projecting into their corresponding cellular compartments.