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. 2024 Feb 22;14(2):e1591. doi: 10.1002/ctm2.1591

FIGURE 6.

FIGURE 6

DOCK7 delivered via TAM‐EVs could upregulate ABCA1 expression via the RAC1/AKT/FOXO1 axis in CRC cells. (A and B) AKT/FOXO1 signalling pathway proteins were analysed by Western blotting in CRC cells treated with or without TAM‐EVs (A) and NSC23766 (B). (C and D) Western blotting was used to analyse ABCA1 and AKT/FOXO1 pathway proteins in CRC cells treated with or without RAW264.7‐NC/OEDOCK7‐EVs combined with NSC23766 (C) or RAW264.7‐shNC/shDOCK7+MC38‐CM combined with ML‐097 (D). (E–H) Immunofluorescence staining was conducted to evaluate the localisation and staining intensity of p‐FOXO1 in CRC cells treated with or without TAM‐EVs (E and F) or treated with or without RAW264.7‐NC/OEDOCK7‐EVs combined with NSC23766 (G and H). Scale bar: 20 μm. The data are presented as the means ± SDs. *p < .05, **p < .01, ***p < .001.