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. 2023 Dec 18;20(1):28–55. doi: 10.1038/s44320-023-00004-7

Figure 4. Drugs with related MoAs share common markers of drug response.

Figure 4

(A) Left panel: cluster of drugs resulting from multiblock partial least-square regression (SMBPLSR) analysis containing MAP2K inhibitors. Middle panel: ranked list of proteins and phosphorylation sites from the SMBPLSR analysis as indicators of drug sensitivity (pink) or resistance (blue). Right panel: correlation between the extent of phenotypic response towards Cobimetinib and the abundance of S100A16. R Pearson correlation coefficient, p P value. (B) same as (A) but for mTOR/PI3K inhibitors. (C) Same as (A) but for AURK and PARP inhibitors.