Table 1.

List of miRNAs deregulated in MYBPC3 variant samples and their association with cardiac disease phenotype and aging

S. No	miRNA	MicroRNA expressions in HCM	Age/senescence/longevity-related changes in microRNA expression
1	miR-377-3p	Peripheral blood miRNAs-upregulated in HCM patients c.3369_3370insC and c.3624delC MYBPC3 mutation[143]	Upregulated in late passaged human skin[272]; miRNA inhibition reduces senescence and increases cell viability[273]
2	miR-103a-3p		Lower in peripheral mononuclear cells of older individuals[203]
3	miR-146b-3p		Upregulated during senescence[274]; lower expression levels in bronchial tissues of elderly[275] and aged macrophages[276] downregulated in perivascular adipose tissue of aged mice with cold stimulus[277]; upregulated in aging heart[278]
4	miR-208b		Upregulated inyoung mice compared to older ones under post-traumatic osteoarthritis[279]
5	miR-200c		Upregulated in aging liver, aged skin[280,281]; upregulation in endothelial cell death and senescence
6	miR-181-5p	Cardiac miRNAs-upregulated in cardiac tissues of HCM patients with c.927–2A>G, c.2373insG mutations[142]	NK cell aging[282,283], age-related loss of muscle cells[284], and skeletal cell aging[285]; downregulated in peripheral blood and associated with all-cause mortality and age-related traits[286]
7	miR-184		Downregulated in calorie-restricted mouse brain[287], older adults with major depressive disorder[288], downregulated in aging heart[278]
8	miR-222-5p		Altered copy number in aging[289]
9	miR-96		Increased with age in peripheral blood mononuclear cells[290]
10	miR-204		Upregulated in aged hippocampus[291]
11	miR-10a	Cardiac miRNAs-upregulated in cardiac tissues of HCM patients with c.927-2A>G, c.2373insG mutations[142]	miR-10b, decreased in PD and increased in HD; both are age-associated diseases[292,293]; downregulated in liver that senesces with aging[294]
12	miR-10b		MiR-10a*/miR-10–3p enriched in exosomes derived from frail, older individuals[295]
13	miR-652-3p	Myocardial miRNA upregulated in HCM[296]	Upregulated in aging heart[278]
14	miR-17-5p	HCM cardiac tissue upregulated miRNA[297]	Upregulated in aging heart[278]
15	miR-29a	Plasma miRNAs upregulated in HCM[298,299]	Upregulated in aging heart[300,301]
16	miR-1–3p	Downregulated in Left ventricular heart tissues[302] and HCM	Elevated levels in colon tissues of older individuals[303]
17	miR-27a		Upregulated in aging heart[278]
18	miR-155	Plasma miRNA downregulated[298]; upregulated[302] in HCM/DCM	Lower in older individuals[203]