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. 2024 Feb 22;17(2):e13743. doi: 10.1111/cts.13743

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© 2024 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Distributions of (a) M444‐, (b) M414‐, and (c) M416‐to‐solanidine metabolic ratios in NFIB C (red dots) versus TT carriers (black dots) among various CYP2D6 phenotype subgroups. The two blue‐square dots represent the two homozygous NFIB C carriers detected in the population. Horizontal lines represent mean values of the respective metabolic ratios (±95% confidence interval). Statistical analyses were performed by Student's t‐test comparing NFIB C versus TT carriers within each CYP2D6 phenotype subgroups. IM intermediate metabolizers; NM, normal metabolizers; PM, poor metabolizers; UM, ultra‐rapid metabolizers.