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. 2015 Sep 23;2015(9):CD004249. doi: 10.1002/14651858.CD004249.pub4

Summary of findings 4. Manipulation compared with exercise for neck pain.

Manipulation compared with exercise for neck pain
Patient or population: patients with acute and subacute neck pain
Settings: ambulatory care or outpatient clinic setting
Intervention: manipulation of cervical region
Comparison: exercise
Outcomes Relative effect
 (95% CI) Number of participants
 (studies) Quality of the evidence
 (GRADE) Comments
PAIN
Acute and subacute neck pain
Intermediate‐term follow‐up
SMD: ‐0.16
(‐0.45 to 0.13)
182
 (1 trial; Bronfort 2012) ⊕⊕⊕⊝
Moderatea
No significant differences between groups
Acute and subacute neck pain
Long‐term follow‐up
SMD: 0.06
(‐0.23 to 0.35)
182
 (1 trial; Bronfort 2012) ⊕⊕⊕⊝
Moderatea
No significant differences between groups
FUNCTION
Acute and subacute neck pain
Intermediate‐term follow‐up
SMD: ‐0.01
(‐0.30 to 0.28)
   
182
 (1 trial; Bronfort 2012) ⊕⊕⊕⊝
Moderatea
No significant differences between groups
Acute and subacute neck pain
Long‐term follow‐up
SMD: ‐0.02
(‐0.31 to 0.27)
   
182
 (1 trial; Bronfort 2012) ⊕⊕⊕⊝
Moderatea
No significant differences between groups
PARTICIPANT SATISFACTION
Acute and subacute neck pain
Long‐term follow‐up
Not estimable 182
 (1 trial; Bronfort 2012) ⊕⊕⊕⊝
Moderatea
Improvement in participant satisfaction for manipulation over exercise
GLOBAL PERCEIVED EFFECT
Acute and subacute neck pain
Immediate post‐treatment follow‐up
Not estimable 182
(1 trial; Bronfort 2012)
⊕⊕⊕⊝
Moderatea
No significant differences between groups
QUALITY OF LIFE
Acute and subacute neck pain
Intermediate‐term follow‐up
SMD: ‐0.05 (‐0.35 to 0.24) 182
 (1 trial; Bronfort 2012) ⊕⊕⊕⊝
Moderatea
No significant differences between groups
Acute and subacute neck pain
Long‐term follow‐up
SMD: 0.0 (‐0.29 to 0.29) 182
 (1 trial; Bronfort 2012) ⊕⊕⊕⊝
Moderatea
No significant differences between groups
Moderate‐quality evidence suggests no differences in pain, function, global perceived effect and quality of life when multiple sessions of cervical manipulation are compared with exercise at immediate‐, intermediate‐ and long‐term follow‐up. Moderate‐quality evidence indicates that use of cervical manipulation led to greater participant satisfaction when compared with an exercise programme at long‐term follow‐up.
GRADE Working Group grades of evidence.
 High quality: Further research is very unlikely to change our confidence in the estimate of effect.
 Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
 Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
 Very low quality: We are very uncertain about the estimate.

aIndirectness: ‐1.