Additional Table 3.
The list of statistical data in the figures
| F-value | A vs. B | Data | P-value | Notes | |
|---|---|---|---|---|---|
| Figure 2B | F (6, 28) =128.30 | I/R 24 h group vs. sham group | 60.40±7.44 vs. 104.40±5.94 | <0.0001 | |
| Figure 2C | F (6, 14) =46.75 | I/R 24 h group vs. Control group | 45.67±5.51 vs. 100.70±8.02 | <0.0001 | |
| Figure 2F | F (6, 28) =45.2 | I/R 24 h group vs. sham group | 2.72±0.77 vs. 1.08±0.04 | <0.0001 | |
| Figure 2H | F (6, 14) =77.5 | I/R 24 h group vs. Control group | 4.32±0.37 vs. 0.94±0.07 | <0.0001 | |
| Figure 2I | F (6, 28) =193.60 | I/R 24 h group vs. sham group | 7.11±0.31 vs. 1.15±0.24 | <0.0001 | |
| Figure 2J | F (6, 14) =89.36 | I/R 24 h group vs. Control group | 7.78±0.51 vs. 1.05±0.02 | <0.0001 | |
| Figure 3B | F (3, 16) =85.47 | I/R+Homer1a OE group vs. I/R group | 78.40±3.98 vs. 56.20±6.02 | 0.0004 | |
| I/R+Homer1a KD group vs. I/R group | 34.40±3.21 vs. 56.20±6.02 | 0.0005 | |||
| Figure 3D | F (3, 16) =194.90 | I/R+Homer1a OE group vs. I/R group | 0.23±0.04 vs. 0.56±0.08 | <0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 0.88±0.07 vs. 0.56±0.08 | <0.0001 | |||
| Figure 3F | F (3, 8) =48.85 | I/R+Homer1a OE group vs. I/R group | 0.22±0.05 vs. 0.61±0.12 | 0.003 | |
| I/R+Homer1a KD group vs. I/R group | 0.89±0.12 vs. 0.61±0.12 | 0.02 | |||
| Figure 3G | F (3, 8) =45.20 | I/R+Homer1a OE group vs. I/R group | 75±6.56 vs. 49.67±6.43 | 0.0128 | |
| I/R+Homer1a KD group vs. I/R group | 25.67±9.07 vs. 49.67±6.43 | 0.0172 | |||
| Figure 4C | F (3, 16) =1365 | I/R+Homer1a OE group vs. I/R group | 975.80±56.58 vs. 46752±2999 | <0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 194737±10708 vs. 46752±2999 | <0.0001 | |||
| Figure 4D | F (3, 16) =1010 | I/R+Homer1a OE group vs. I/R group | 1296±212.80 vs. 24593±1739 | <0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 80556±4969 vs. 24593±1739 | <0.0001 | |||
| Figure 4E | F (3, 16) =242.40 | I/R+Homer1a OE group vs. I/R group | 1400±241.40 vs. 3862±535.50 | <0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 5667±157.10 vs. 3862±535.50 | <0.0001 | |||
| Figure 4F | F (3, 16) =687.30 | I/R+Homer1a OE group vs. I/R group | 749.40±68.86 vs. 4301±197.60 | 0.0006 | |
| I/R+Homer1a KD group vs. I/R group | 27629±2209 vs. 4301±197.60 | <0.0001 | |||
| Figure 4G | F (3, 16) =275 | I/R+Homer1a OE group vs. I/R group | 1020±89.91 vs. 10734±892.20 | <0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 13420±1551 vs. 10734±892.20 | 0.0012 | |||
| Figure 5B | F (3, 16) =165.3 | I/R+Homer1a OE group vs. I/R group | 1.31±0.13 vs. 1.96±0.13 | <0.0001 | Caspase-8 |
| I/R+Homer1a KD group vs. I/R group | 2.81±0.18 vs. 1.96±0.13 | <0.0001 | |||
| Figure 5C | F (3, 16) =102.8 | I/R+Homer1a OE group vs. I/R group | 1.38±0.14 vs. 1.91±0.31 | 0.0186 | NLRP3 |
| I/R+Homer1a KD group vs. I/R group | 3.52±0.32 vs. 1.91±0.31 | <0.0001 | |||
| Figure 5D | F (3, 16) =47.98 | I/R+Homer1a OE group vs. I/R group | 1.32±0.10 vs. 1.74±0.15 | 0.0261 | ASC |
| I/R+Homer1a KD group vs. I/R group | 2.40±0.36vs. 1.74±0.15 | 0.0006 | |||
| Figure 5E | F (3, 16) =284.5 | I/R+Homer1a OE group vs. I/R group | 1.50±0.12 vs. 2.27±0.15 | <0.0001 | Cleaved Caspase-1/Caspase-1 |
| I/R+Homer1a KD group vs. I/R group | 3.87±0.24 vs. 2.27±0.15 | <0.0001 | |||
| Figure 5G | F (3, 8) =49.44 | I/R+Homer1a OE group vs. I/R group | 1.43±0.08 vs. 1.84±0.09 | 0.0391 | Caspase-8 |
| I/R+Homer1a KD group vs. I/R group | 2.43±0.27 vs. 1.84±0.09 | 0.0055 | |||
| Figure 5H | F (3, 8) =80.67 | I/R+Homer1a OE group vs. I/R group | 1.68±0.25 vs. 2.34±0.12 | 0.0053 | NLRP3 |
| I/R+Homer1a KD group vs. I/R group | 2.89±0.14 vs. 2.34±0.12 | 0.0136 | |||
| Figure 5I | F (3, 8) =49.91 | I/R+Homer1a OE group vs. I/R group | 1.35±0.12 vs. 1.73±0.05 | 0.0233 | ASC |
| I/R+Homer1a KD group vs. I/R group | 2.14±0.20 vs. 1.73±0.05 | 0.0166 | |||
| Figure 5J | F (3, 8) =51.39 | I/R+Homer1a OE group vs. I/R group | 1.61±0.15 vs. 2.24±0.27 | 0.0128 | Cleaved Caspase-1/Caspase-1 |
| I/R+Homer1a KD group vs. I/R group | 2.77±0.11 vs. 2.24±0.27 | 0.0341 | |||
| Figure 7A | F (3, 16) =111.30 | I/R+Homer1a OE group vs. I/R group | 821.80±53.12 vs. 1123±178 | 0.0017 | |
| I/R+Homer1a KD group vs. I/R group | 1756±93.16 vs. 1123±178 | <0.0001 | |||
| Figure 7B | F (3, 16) =324.10 | I/R+Homer1a OE group vs. I/R group | 1081±51.21 vs. 1674±148.50 | <0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 2776±139.70 vs. 1674±148.50 | <0.0001 | |||
| Figure 7C | F (3, 8) =434.50 | I/R+Homer1a OE group vs. I/R group | 951.70±22.48 vs. 1538±135.80 | 0.0002 | |
| I/R+Homer1a KD group vs. I/R group | 3110±95.63 vs. 1538±135.80 | <0.0001 | |||
| Figure 7D | F (3, 8) =508.50 | I/R+Homer1a OE group vs. I/R group | 972.30±62.00 vs. 1582±26.16 | 0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 3108±106.30 vs. 1582±26.16 | <0.0001 | |||
| Figure 7F | F (3, 16) =149.7 | I/R+Homer1a OE group vs. I/R group | 1.68±0.13 vs. 2.10±0.21 | 0.0118 | Cleaved-IL-1β/IL-1β |
| I/R+Homer1a KD group vs. I/R group | 3.40±0.23 vs. 2.10±0.21 | <0.0001 | |||
| Figure 7G | F (3, 16) =61.75 | I/R+Homer1a OE group vs. I/R group | 1.34±0.11 vs. 1.67±0.21 | 0.0231 | Cleaved-IL-18/IL-18 |
| I/R+Homer1a KD group vs. I/R group | 2.32±0.14 vs. 1.67±0.21 | <0.0001 | |||
| Figure 7I | F (3, 8) =69.76 | I/R+Homer1a OE group vs. I/R group | 1.50±0.15 vs. 2.38±0.19 | 0.0014 | Cleaved-IL-1β/IL-1β |
| I/R+Homer1a KD group vs. I/R group | 2.89±0.23 vs. 2.38±0.19 | 0.0305 | |||
| Figure 7J | F (3, 8) =246.7 | I/R+Homer1a OE group vs. I/R group | 1.35±0.06 vs. 1.80±0.06 | 0.0016 | Cleaved-IL-18/IL-18 |
| I/R+Homer1a KD group vs. I/R group | 2.91±0.15 vs. 1.80±0.06 | <0.0001 | |||
| Figure 7K | F (3, 16) =1389 | I/R+Homer1a OE group vs. I/R group | 2.02±0.14 vs. 3.97±0.09 | <0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 6.07±0.18 vs. 3.97±0.09 | <0.0001 | |||
| Figure 7L | F (3, 16) =164.2 | I/R+Homer1a OE group vs. I/R group | 1.95±0.60 vs. 3.76±0.33 | <0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 5.83±0.27 vs. 3.76±0.33 | <0.0001 | |||
| Figure 7M | F (3, 8) =1188 | I/R+Homer1a OE group vs. I/R group | 1.97±0.10 vs. 4.01±0.15 | <0.0001 | |
| I/R+Homer1a KD group vs. I/R group | 5.98±0.08 vs. 4.01±0.15 | <0.0001 | |||
| Figure 7N | F (3, 8) =55.43 | I/R+Homer1a OE group vs. I/R group | 2.04±0.24 vs. 4.16±0.32 | 0.0041 | |
| I/R+Homer1a KD group vs. I/R group | 5.89±0.93 vs. 4.16±0.32 | 0.0132 | |||
| Figure 8B | F (6, 28) =63.83 | I/R 24 h group vs. sham group | 2.35±0.11 vs. 1.04±0.08 | <0.0001 | |
| Figure 8E | F (6, 28) =472.50 | I/R 24 h group vs. sham group | 7.11±0.24 vs. 1.22±0.22 | <0.0001 | |
| Figure 8D | F (6, 14) =249.1 | I/R 24 h group vs. Control group | 3.46±0.11 vs. 1.00±0.03 | <0.0001 | |
| Figure 8F | F (6, 14) =139.60 | I/R 24 h group vs. Control group | 8.35±0.33 vs. 0.97±0.09 | <0.0001 | |
| Figure 8H | F (3, 16) =35.23 | I/R+Homer1a OE group vs. I/R group | 1.42±0.17 vs. 1.73±0.14 | 0.0452 | |
| I/R+Homer1a KD group vs. I/R group | 2.06±0.16 vs. 1.73±0.14 | 0.0337 | |||
| Figure 8J | F (3, 8) =97.66 | I/R+Homer1a OE group vs. I/R group | 1.27±0.04 vs. 1.47±0.07 | 0.0151 | |
| I/R+Homer1a KD group vs. I/R group | 1.83±0.08 vs. 1.47±0.07 | 0.0004 | |||
| Figure 8L | F (3, 16) =78.07 | I/R+Homer1a OE group vs. I/R group | 1.47±0.07 vs. 1.76±0.12 | 0.0482 | Cytoplasm |
| I/R+Homer1a KD group vs. I/R group | 2.51±0.25 vs. 1.76±0.12 | <0.0001 | |||
| Figure 8N | F (3, 16) =278 | I/R+Homer1a OE group vs. I/R group | 1.39±0.24vs. 2.98±0.15 | <0.0001 | Nucleus |
| I/R+Homer1a KD group vs. I/R group | 4.93±0.26 vs. 2.98±0.15 | <0.0001 | |||
| Figure 8P | F (3, 8) =79.06 | I/R+Homer1a OE group vs. I/R group | 1.25±0.05 vs. 1.52±0.09 | 0.0084 | Cytoplasm |
| I/R+Homer1a KD group vs. I/R group | 1.87±0.10 vs. 1.52±0.09 | 0.0017 | |||
| Figure 8R | F (3, 8) =55.28 | I/R+Homer1a OE group vs. I/R group | 1.28±0.09 vs. 1.65±0.07 | 0.0254 | Nucleus |
| I/R+Homer1a KD group vs. I/R group | 2.21±10.21 vs. 1.65±0.07 | 0.0022 | |||
| Figure 9B | F (2, 12) =48.47 | I/R+NF-κB inh group vs. I/R group | 1.41±0.10 vs. 1.81±0.12 | 0.0005 | NLRP3 |
| Figure 9C | F (2, 12) = 11.00 | I/R+NF-κB inh group vs. I/R group | 1.16±0.16 vs. 1.49±0.15 | 0.0195 | Cleaved-IL-1β/IL-1β |
| Figure 9D | F (2, 12) = 7.098 | I/R+NF-κB inh group vs. I/R group | 1.46±0.28 vs. 1.48±0.19 | 0.9878 | Caspase-8 |
| Figure 9E | F (2, 12) = 62.64 | I/R+NF-κB inh group vs. I/R group | 1.24±0.12 vs. 2.12±0.19 | <0.0001 | Cleaved-IL-18/IL-18 |
| Figure 9G | F (2, 6) =94.97 | I/R+NF-κB inh group vs. I/R group | 1.42±0.11 vs. 1.88±0.08 | 0.0014 | NLRP3 |
| Figure 9H | F (2, 6) = 304.1 | I/R+NF-κB inh group vs. I/R group | 1.43±0.05 vs. 2.38±0.10 | <0.0001 | Cleaved-IL-1β/IL-1β |
| Figure 9I | F (2, 6) = 29.62 | I/R+NF-κB inh group vs. I/R group | 1.74±0.13 vs. 1.54±0.12 | 0.1608 | Caspase-8 |
| Figure 9J | F (2, 6) = 40.26 | I/R+NF-κB inh group vs. I/R group | 1.26±0.45 vs. 2.89±0.09 | 0.0009 | Cleaved-IL-18/IL-18 |
| Figure 9L | F (2, 12) = 26.44 | I/R+Caspase-8 inh group vs. I/R group | 1.43±0.09 vs. 1.74±0.22 | 0.0189 | |
| Figure 9N | F (2, 6) = 61.86 | I/R+Caspase-8 inh group vs. I/R group | 1.34±0.06 vs. 1.91±0.03 | 0.0007 | |
| Figure 10E | F (4, 20) =135.90 | I/R+ NF-κB inh group vs. I/R group | 0.28±0.02 vs. 0.61±0.05 | <0.0001 | |
| I/R+Homer1a protein group vs. I/R group | 0.304±0.019 vs. 0.612±0.051 | <0.0001 | |||
| I/R+both group vs. I/R group | 0.15±0.04 vs. 0.61±0.05 | <0.0001 | |||
| I/R+ NF-κB inh group vs. I/R+both group | 0.28±0.02 vs. 0.15±0.04 | 0.0001 | |||
| I/R+Homer1a protein group vs. I/R+both group | 0.30±0.02 vs. 0.15±0.04 | <0.0001 | |||
| Figure 10F | F (4, 10) =83.73 | I/R+ NF-κB inh group vs. I/R group | 0.29±0.05 vs. 0.61±0.06 | <0.0001 | |
| I/R+Homer1a protein group vs. I/R group | 0.31±0.03 vs. 0.61±0.06 | <0.0001 | |||
| I/R+both group vs. I/R group | 0.11±0.01 vs. 0.61±0.06 | <0.0001 | |||
| Figure 10G | F (4, 20) =43.52 | I/R+ NF-κB inh group vs. I/R group | 70.40±6.66 vs. 46.40±4.04 | 0.0003 | |
| I/R+Homer1a protein group vs. I/R group | 70.60±7.34 vs. 46.40±4.04 | 0.0003 | |||
| I/R+both group vs. I/R group | 90.60±4.93 vs. 46.40±4.04 | <0.0001 | |||
| I/R+ NF-κB inh group vs. I/R+both group | 70.40±6.66 vs. 90.60±4.93 | 0.0022 | |||
| I/R+Homer1a protein group vs. I/R+both group | 70.60±7.34 vs. 90.60±4.93 | 0.0025 | |||
| Additional Figure 2A (6MB, tif) | F (5, 24) = 1783 | AAV2/DJ-Homer1a group vs. NC1 group | 5.50±0.21 vs. 0.95±0.03 | <0.0001 | |
| AAV2/DJ-Homer1a-RNAi-1 vs. NC2 group | 0.38±0.10 vs. 0.99±0.06 | <0.0001 | |||
| AAV2/DJ-Homer1a-RNAi-2 vs. NC2 group | 0.80±0.06 vs. 0.99±0.06 | 0.0589 | |||
| AAV2/DJ-Homer1a-RNAi-3 vs. NC2 group | 0.76±0.06 vs. 0.99±0.06 | 0.0129 | |||
| Additional Figure 2F (6MB, tif) | F (5, 12) = 236.40 | LV-Homer1a group vs. NC1group | 6.09±0.57 vs. 1.05±0.05 | <0.0001 | |
| LV-Homer1a-RNAi-1 vs. NC2 group | 0.20±0.08 vs. 0.96±0.13 | 0.03 | |||
| LV-Homer1a-RNAi-2 vs. NC2 group | 0.77±0.08 vs. 0.96±0.13 | 0.93 | |||
| LV-Homer1a-RNAi-3 vs. NC2 group | 0.72±0.11 vs. 0.96±0.13 | 0.84 | |||
| Additional Figure 3A (5.6MB, tif) | F (3, 16) =83.23 | I/R group vs. Sham group | 0.46±0.06 vs. 0.01±0.00 | <0.0001 | |
| I/R+Homer1a OE group vs. I/R group | 0.09±0.00 vs. 0.46±0.06 | <0.0001 | |||
| I/R+Homer1a KD group vs. I/R group | 0.65±0.14 vs. 0.46±0.06 | 0.0041 | |||
| Additional Figure 3B (5.6MB, tif) | F (3, 16) =206.40 | I/R group vs. Sham group | 0.37±0.05 vs. 0.01±0.00 | <0.0001 | |
| I/R+Homer1a OE group vs. I/R group | 0.11±0.01 vs. 0.37±0.05 | <0.0001 | |||
| I/R+Homer1a KD group vs. I/R group | 0.78±0.09 vs. 0.37±0.05 | <0.0001 | |||
| Additional Figure 3C (5.6MB, tif) | F (3, 16) =1052 | I/R group vs. Sham group | 0.45±0.04 vs. 0.01±0.00 | <0.0001 | |
| I/R+Homer1a OE group vs. I/R group | 0.12±0.00 vs. 0.45±0.04 | <0.0001 | |||
| I/R+Homer1a KD group vs. I/R group | 0.86±0.03 vs. 0.45±0.04 | <0.0001 | |||
| Additional Figure 3D (5.6MB, tif) | F (3, 16) =400.60 | I/R group vs. Sham group | 0.56±0.07 vs. 0.01±0.00 | <0.0001 | |
| I/R+Homer1a OE group vs. I/R group | 0.09±0.01 vs. 0.56±0.07 | <0.0001 | |||
| I/R+Homer1a KD group vs. I/R group | 0.87±0.06 vs. 0.56±0.07 | <0.0001 | |||
| Additional Figure 3E (5.6MB, tif) | F (3, 8) =100.70 | I/R group vs. Control group | 0.71±0.08 vs. 0.01±0.00 | <0.0001 | |
| I/R+Homer1a OE group vs. I/R group | 0.52±0.09 vs. 0.71±0.08 | 0.04 | |||
| I/R+Homer1a KD group vs. I/R group | 0.99±0.08 vs. 0.71±0.08 | 0.01 | |||
| Additional Figure 3F (5.6MB, tif) | F (3, 8) =644.80 | I/R group vs. Control group | 0.87±0.02 vs. 0.01±0.00 | <0.0001 | |
| I/R+Homer1a OE group vs. I/R group | 0.50±0.05 vs. 0.87±0.02 | <0.0001 | |||
| I/R+Homer1a KD group vs. I/R group | 1.00±0.04 vs. 0.87±0.02 | 0.02 | |||
| Additional Figure 3G (5.6MB, tif) | F (3, 8) =338.60 | I/R group vs. Control group | 0.87±0.04 vs. 0.01±0.00 | <0.0001 | |
| I/R+Homer1a OE group vs. I/R group | 0.50±0.04 vs. 0.87±0.04 | <0.0001 | |||
| I/R+Homer1a KD group vs. I/R group | 1.00±0.07 vs. 0.87±0.04 | 0.01 | |||
| Additional Figure 3H (5.6MB, tif) | F (3, 8) =353.00 | I/R group vs. Control group | 0.56±0.03 vs. 0.01±0.00 | <0.0001 | |
| I/R+Homer1a OE group vs. I/R group | 0.37±0.06 vs. 0.56±0.03 | 0.0005 | |||
| I/R+Homer1a KD group vs. I/R group | 0.86±0.01 vs. 0.56±0.03 | <0.0001 | |||
| Additional Figure 4B (4.1MB, tif) | F (3, 16) =1.438 | NF-B inh group vs. Sham group | 96.20±3.56 vs. 100.00±2.35 | 0.3096 | |
| Homer1a protein group vs. Sham group | 95.20±4.09 vs. 100.00±2.35 | 0.1595 | |||
| both group vs. Sham group | 97.40±4.98 vs. 100.00±2.35 | 0.5923 | |||
| Additional Figure 4C (4.1MB, tif) | F (3, 8) =1.455 | NF-B inh group vs. Control group | 96.00±1.73 vs. 98.67±1.53 | 0.254 | |
| Homer1a protein group vs. Control group | 96.33±1.16 vs. 98.67±1.53 | 0.3418 | |||
| both group vs. Control group | 96.00±2.65 vs. 98.67±1.53 | 0.254 |