Table 2. Pathological observations on the clones.
| Clone
|
||||
|---|---|---|---|---|
| Organ | Examination level | Observation | 1 | 2 |
| Liver | Gross appearance | Normal | Normal | |
| Histological findings | Irregular arrangement of hepatic cords | — | — | |
| Focal necrosis | — | — | ||
| Inflammation | — | — | ||
| Fibrosis | — | — | ||
| Kidney | Gross appearance | Structure | Normal | Normal |
| Urinary calculus (collecting duct) | +* | +* | ||
| Histological findings | ||||
| Cortex | ||||
| Glomerulus | Varying size | — | — | |
| Immature form | — | — | ||
| Proliferation of the mesangial cells | — | — | ||
| Thickened basement membrane | — | — | ||
| Renal tubules | Cystic tubules | — | — | |
| Urinary casts | — | — | ||
| Atrophied or immature tubules | — | — | ||
| Thickened basement membrane | — | — | ||
| Abnormal cell infiltration | — | — | ||
| Medulla | Urinary cast | — | — | |
| Cystic tubule | — | — | ||
| Inflammation | — | — | ||
| Lung | Gross appearance | Normal | Normal | |
| Histological findings | Atelectasis | — | — | |
| Inflammation | — | — | ||
| Heart | Gross appearance | Normal | Normal | |
| Histological findings | ||||
| Cardiac muscle cells | Irregular arrangement | — | — | |
| Necrosis | — | — | ||
| Inflammation | — | — | ||
| Spleen | Gross appearance | Normal | Normal | |
| Histological findings | ||||
| Inflammation | — | — | ||
| Hyperplasia | — | — | ||
| Adrenal gland | Gross appearance | Normal | Normal | |
| Histological findings | Irregular arrangement of cortex cells | — | — | |
| Hyperplasia | — | — | ||
| Thyroid | Gross appearance | Normal | Normal | |
| Histological findings | Abnormal follicles | — | — | |
| Abnormal follicular epithelium | — | — | ||
*
Significant difference was detected between clones and comparators.