Table 2. Pathological observations on the clones.
Clone
|
||||
---|---|---|---|---|
Organ | Examination level | Observation | 1 | 2 |
Liver | Gross appearance | Normal | Normal | |
Histological findings | Irregular arrangement of hepatic cords | — | — | |
Focal necrosis | — | — | ||
Inflammation | — | — | ||
Fibrosis | — | — | ||
Kidney | Gross appearance | Structure | Normal | Normal |
Urinary calculus (collecting duct) | +* | +* | ||
Histological findings | ||||
Cortex | ||||
Glomerulus | Varying size | — | — | |
Immature form | — | — | ||
Proliferation of the mesangial cells | — | — | ||
Thickened basement membrane | — | — | ||
Renal tubules | Cystic tubules | — | — | |
Urinary casts | — | — | ||
Atrophied or immature tubules | — | — | ||
Thickened basement membrane | — | — | ||
Abnormal cell infiltration | — | — | ||
Medulla | Urinary cast | — | — | |
Cystic tubule | — | — | ||
Inflammation | — | — | ||
Lung | Gross appearance | Normal | Normal | |
Histological findings | Atelectasis | — | — | |
Inflammation | — | — | ||
Heart | Gross appearance | Normal | Normal | |
Histological findings | ||||
Cardiac muscle cells | Irregular arrangement | — | — | |
Necrosis | — | — | ||
Inflammation | — | — | ||
Spleen | Gross appearance | Normal | Normal | |
Histological findings | ||||
Inflammation | — | — | ||
Hyperplasia | — | — | ||
Adrenal gland | Gross appearance | Normal | Normal | |
Histological findings | Irregular arrangement of cortex cells | — | — | |
Hyperplasia | — | — | ||
Thyroid | Gross appearance | Normal | Normal | |
Histological findings | Abnormal follicles | — | — | |
Abnormal follicular epithelium | — | — |
Significant difference was detected between clones and comparators.