TABLE 2.
Univariate and multivariate Cox regression analyses.
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p‐value | HR (95% CI) | p‐value | |
| Age/year | ||||
| ≤40 | Reference | Reference | ||
| >40 | 0.507 (0.213–1.205) | 0.124 | 0.352 (0.140–0.885) | 0.026 |
| Histological grade | ||||
| I–II | Reference | Reference | ||
| III | 2.783 (1.077–7.190) | 0.035 | 2.759 (1.051–7.238) | 0.039 |
| Tumor size/cm | ||||
| ≤2 | Reference | |||
| >2 | 1.025 (0.434–2.422) | 0.955 | ||
| Lymph node status | ||||
| Negative | Reference | Reference | ||
| Positive | 2.828 (1.034–7.731) | 0.043 | 4.107 (1.423–11.853) | 0.009 |
| Ki67 | ||||
| <30% | Reference | |||
| ≥30% | 2.052 (0.593–7.105) | 0.257 | ||
| ER status | ||||
| <50% | Reference | |||
| ≥50% | 0.590 (0.227–1.536) | 0.280 | ||
| PR status | ||||
| <50% | Reference | Reference | ||
| ≥50% | 0.239 (0.093–0.616) | 0.003 | 0.294 (0.112–0.770) | 0.013 |
| LVI | ||||
| Negative | Reference | |||
| Positive | 1.589 (0.613–4.121) | 0.341 | ||
| Surgery | ||||
| Lumpectomy | Reference | |||
| Mastectomy | 0.887 (0.321–2.447) | 0.817 | ||
| Chemotherapy regimen | ||||
| Non‐anthracycline | Reference | |||
| Anthracycline‐based | 0.901 (0.346–2.348) | 0.831 | ||
| Endocrine therapy | ||||
| TAM/TOR‐only | Reference | Reference | ||
| TAM/TOR/AI+OFS | 0.406 (0.149–1.110) | 0.079 | 0.289 (0.100–0.835) | 0.022 |
Abbreviations: CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; LVI, lymphovascular invasion; OFS, ovarian function suppression; PR, progesterone receptor; TAM, tamoxifen; TOR, toremifene.