Table 1.
Patient characteristics in the study.
| Variable | EOCRC | LOCRC | p |
|---|---|---|---|
| Gender | 0.019 | ||
| Male | 5368 (53.5%) | 30,791 (54.8%) | |
| Female | 4668 (46.5%) | 25,434 (45.2%) | |
| Year of diagnosis | 0.020 | ||
| 2010 | 897 (8.94%) | 5340 (9.50%) | |
| 2011 | 925 (9.22%) | 5419 (9.64%) | |
| 2012 | 904 (9.01%) | 5366 (9.54%) | |
| 2013 | 988 (9.84%) | 5343 (9.50%) | |
| 2014 | 982 (9.78%) | 5698 (10.1%) | |
| 2015 | 976 (9.72%) | 5608 (9.97%) | |
| 2016 | 1067 (10.6%) | 5768 (10.3%) | |
| 2017 | 1122 (11.2%) | 5725 (10.2%) | |
| 2018 | 1065 (10.6%) | 5905 (10.5%) | |
| 2019 | 1110 (11.1%) | 6053 (10.8%) | |
| Race | < 0.001 | ||
| White | 7351 (73.2%) | 43,306 (77.0%) | |
| Black | 1486 (14.8%) | 7718 (13.7%) | |
| American Indian | 119 (1.19%) | 491 (0.87%) | |
| Asian | 1028 (10.2%) | 4556 (8.10%) | |
| Unknown | 52 (0.52%) | 154 (0.27%) | |
| Primary site | < 0.001 | ||
| Right-sided | 2177 (21.7%) | 19,307 (34.3%) | |
| Left-sided | 3204 (31.9%) | 13,827 (24.6%) | |
| Rectum | 2405 (24.0%) | 10,479 (18.6%) | |
| Others | 2250 (22.4%) | 12,612 (22.4%) | |
| Histological type | < 0.001 | ||
| Adenocarcinoma | 9535 (95.0%) | 52,685 (93.7%) | |
| Others | 501 (4.99%) | 3540 (6.30%) | |
| T | < 0.001 | ||
| T1 | 697 (6.94%) | 4307 (7.66%) | |
| T2 | 245 (2.44%) | 1199 (2.13%) | |
| T3 | 3180 (31.7%) | 16,160 (28.7%) | |
| T4 | 3132 (31.2%) | 15,816 (28.1%) | |
| Unknown | 2782 (27.7%) | 18,743 (33.3%) | |
| N | < 0.001 | ||
| N0 | 2715 (27.1%) | 18,135 (32.3%) | |
| N1 | 3080 (30.7%) | 15,429 (27.4%) | |
| N2 | 2553 (25.4%) | 11,924 (21.2%) | |
| Unknown | 1688 (16.8%) | 10,737 (19.1%) | |
| Grade | < 0.001 | ||
| 1/2 | 5674 (56.5%) | 29,314 (52.1%) | |
| 3/4 | 2245 (22.4%) | 12,357 (22.0%) | |
| Unknown | 2117 (21.1%) | 14,554 (25.9%) | |
| Surgery | < 0.001 | ||
| No | 4367 (43.5%) | 28,521 (50.7%) | |
| Yes | 5669 (56.5%) | 27,704 (49.3%) | |
| Radiation | < 0.001 | ||
| No | 8339 (83.1%) | 49,786 (88.5%) | |
| Yes | 1697 (16.9%) | 6439 (11.5%) | |
| Chemotherapy | 0.000 | ||
| No | 1486 (14.8%) | 20,939 (37.2%) | |
| Yes | 8550 (85.2%) | 35,286 (62.8%) | |
| CEA | < 0.001 | ||
| Negative/Borderline | 1503 (15.0%) | 6891 (12.3%) | |
| Positive | 5907 (58.9%) | 31,239 (55.6%) | |
| Unknown | 2626 (26.2%) | 18,095 (32.2%) | |
| Marital status | 0.000 | ||
| Married | 5236 (52.2%) | 27,871 (49.6%) | |
| Single/unmarried | 3309 (33.0%) | 10,412 (18.5%) | |
| Divorced/widowed/separated | 1019 (10.2%) | 15,154 (27.0%) | |
| Unknown | 472 (4.70%) | 2788 (4.96%) | |
| Bone metastases | 0.002 | ||
| No | 9216 (91.8%) | 51,121 (90.9%) | |
| Yes | 568 (5.66%) | 3343 (5.95%) | |
| Unknown | 252 (2.51%) | 1761 (3.13%) | |
| Brain metastases | < 0.001 | ||
| No | 9675 (96.4%) | 53,580 (95.3%) | |
| Yes | 102 (1.02%) | 753 (1.34%) | |
| Unknown | 259 (2.58%) | 1892 (3.37%) | |
| Liver metastases | 0.011 | ||
| No | 2934 (29.2%) | 15,972 (28.4%) | |
| Yes | 6972 (69.5%) | 39,324 (69.9%) | |
| Unknown | 130 (1.30%) | 929 (1.65%) | |
| Lung metastases | < 0.001 | ||
| No | 7657 (76.3%) | 40,667 (72.3%) | |
| Yes | 2102 (20.9%) | 13,735 (24.4%) | |
| Unknown | 277 (2.76%) | 1823 (3.24%) |