Table 2.
Univariable and multivariate Cox regression analysis based on all variables for overall survival of EOCRC patients.
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95%CI) | p | HR (95%CI) | p | |
| Gender | ||||
| Male | [Reference] | [Reference] | ||
| Female | 0.902(0.859–0.947) | < 0.001 | 0.976(0.929–1.026) | 0.337 |
| Race | ||||
| White | [Reference] | [Reference] | ||
| Black | 1.260(1.178–1.347) | < 0.001 | 1.176(1.098–1.260) | < 0.001 |
| American Indian | 0.935(0.741–1.180) | 0.571 | 1.050(0.831–1.327) | 0.681 |
| Asian | 0.981(0.904–1.065) | 0.648 | 0.963(0.886–1.046) | 0.371 |
| Unknown | 0.538(0.312–0.927) | < 0.05 | 0.4759(0.276–0.821) | < 0.01 |
| Primary site | ||||
| Right | [Reference] | [Reference] | ||
| Left | 0.728(0.681–0.778) | < 0.001 | 0.773(0.722–0.826) | < 0.001 |
| Rectum | 0.736(0.686–0.791) | < 0.001 | 0.656(0.604–0.712) | < 0.001 |
| Others | 0.749(0.697–0.805) | < 0.001 | 0.808(0.750–0.871) | < 0.001 |
| Histological type | ||||
| Adenocarcinoma | [Reference] | [Reference] | ||
| Others | 1.362(1.225–1.513) | < 0.001 | 0.924(0.824–1.035) | 0.172 |
| T | ||||
| T1 | [Reference] | [Reference] | ||
| T2 | 0.463(0.381–0.561) | < 0.001 | 0.655(0.537–0.798) | < 0.001 |
| T3 | 0.548(0.497–0.604) | < 0.001 | 0.850(0.765–0.950) | < 0.01 |
| T4 | 0.753(0.684–0.828) | < 0.001 | 1.083(0.976–1.202) | 0.135 |
| Unknown | 1.144(1.039–1.260) | < 0.01 | 0.986(0.893–1.088) | 0.772 |
| N | ||||
| N0 | [Reference] | [Reference] | ||
| N1 | 0.965(0.905–1.029) | 0.274 | 1.166(1.090–1.248) | < 0.001 |
| N2 | 1.031(0.964–1.102) | 0.379 | 1.485(1.374–1.605) | < 0.001 |
| Unknown | 1.622(1.499–1.754) | < 0.001 | 1.113(1.025–1.209) | < 0.05 |
| Grade | ||||
| 1/2 | [Reference] | [Reference] | ||
| 3/4 | 1.954(1.843–2.072) | < 0.001 | 2.013(1.893–2.141) | < 0.001 |
| Unknown | 1.882(1.769–2.003) | < 0.001 | 1.246(1.164–1.334) | < 0.001 |
| Surgery | ||||
| No | [Reference] | [Reference] | ||
| Yes | 0.416(0.395–0.437) | < 0.001 | 0.396(0.368–0.425) | < 0.001 |
| Radiation | ||||
| No | [Reference] | [Reference] | ||
| Yes | 0.800(0.748–0.855) | < 0.001 | 0.885(0.819–0.956) | < 0.01 |
| Chemotherapy | ||||
| No | [Reference] | [Reference] | ||
| Yes | 0.487(0.456–0.519) | < 0.001 | 0.475(0.443–0.509) | < 0.001 |
| CEA | ||||
| Negative/Borderline | [Reference] | [Reference] | ||
| Positive | 1.603(1.485–1.730) | < 0.001 | 1.345(1.244–1.454) | < 0.001 |
| Unknown | 1.451(1.335–1.578) | < 0.001 | 1.174(1.077–1.280) | < 0.001 |
| Marital status | ||||
| Married | [Reference] | [Reference] | ||
| Single/Unmarried | 1.291(1.223–1.363) | < 0.001 | 1.208(1.142–1.277) | < 0.001 |
| Divorced/Widowed/Separated | 1.251(1.154–1.357) | < 0.001 | 1.253(1.154–1.360) | < 0.001 |
| Unknown | 1.098(0.977–1.234) | 0.116 | 1.001(0.890–1.126) | 0.989 |
| Bone metastases | ||||
| No | [Reference] | [Reference] | ||
| Yes | 2.338(2.125–2.572) | < 0.001 | 1.647(1.489–1.822) | < 0.001 |
| Unknown | 1.351(1.172–1.559) | < 0.001 | 1.085(0.799–1.472) | 0.602 |
| Brain metastases | ||||
| No | [Reference] | [Reference] | ||
| Yes | 2.289(1.855–2.826) | < 0.001 | 1.746(1.405–2.171) | < 0.001 |
| Unknown | 1.261(1.094–1.454) | < 0.01 | 0.731(0.549–0.973) | < 0.05 |
| Liver metastases | ||||
| No | [Reference] | [Reference] | ||
| Yes | 1.325(1.254–1.401) | < 0.001 | 1.353(1.276–1.436) | < 0.001 |
| Unknown | 1.443(1.175–1.773) | < 0.001 | 1.226(0.939–1.601) | 0.134 |
| Lung metastases | ||||
| No | [Reference] | [Reference] | ||
| Yes | 1.495(1.410–1.585) | < 0.001 | 1.259(1.184–1.339) | < 0.001 |
| Unknown | 1.502(1.309–1.723) | < 0.001 | 1.381(1.136–1.679) | < 0.01 |