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Diverse tumor types in NK1-transgenic mice. (A) Hepatocellular adenoma (t) and adjacent normal liver (a) in an 18-month-old NK1 male. (B) Adenocarcinoma of the mammary gland in a 21-month-old virgin NK1 female. (C) Melanoma in the brain of the male used for panel A. Dark areas show positive immunohistochemical staining for the melanocyte marker HMB-45. Tissues in panels A and B were stained with hematoxylin and eosin. Magnifications, ×50 (A and B) and ×25 (C).
