Table 1.

Change of intestinal microbiota in HT patients

Cohort	Country	Method	Increase	Decrease	References
HT versus healthy individuals	Brazil	Real-time PCR	Bacteroides	Bifidobacterium	[24]
HT versus healthy individuals	China	16S rRNA gene sequencing	Blautia Roseburia Ruminococcus Romboutsia Dorea Fusicatenibacter Eubacterium	Faecalibacterium Bacteroides Prevotella_9 Lachnoclostridium	[35]
HT versus healthy individuals	China	PCR-DGGE, Real-time PCR, 16S rRNA gene sequencing	Proteobacteria Cyanobacteria Actinobacteria Enterobacteriaceae Alcaligenaceae	Firmicutes Bacteroidetes Veillonelliaceae Prevotellaceae Dialister Bifidobacterium Lactobacillus	[36]
HT with ab/normal thyroid function versus healthy individuals	China	16S rRNA gene sequencing	Akkermansia Lachnospiraceae Bifidobacterium Shuttleworthia Clostriworthdia	Lachnoclostridium Bilophila	[37]
HT with ab/normal thyroid function versus healthy individuals	China	16S rRNA gene sequencing	Phascolarctobacterium Lachnospiraceae_ Lactonifactor Alistipes Subdoligranulum	–	[41]
Primary hypothyroidism versus healthy individuals	China	16S rRNA gene sequencing	Neisseria Rheinheimera	Veillonella Paraprevotella	[23]
HT versus GD and healthy individuals	Spanish	16S rRNA gene sequencing	Victivallaceae Streptococcus Rikenellaceae	Faecalibacterium	[38]