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. 2024 Feb 22;74(1):24. doi: 10.1007/s12031-023-02187-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Analysis of gene expression profiles after the exposure of HT22 cells to hemin. A Results of cluster analysis. The X-coordinate represents the sample name, the Y-coordinate represents the corresponding sample name, and the color represents the correlation coefficient. B Results of principal component analysis (PCA). C Heatmaps of mRNA expressions in the hemin-treated and control groups. Red represents highly expressed RNAs and blue represents mRNAs with low expression. D The volcano plot and statistic of differentially expressed genes (DEGs) in the control and hemin-treated groups. Gray dots represent RNAs that are not significantly different, and red (upregulated mRNAs) and green (downregulated mRNAs) dots represent RNAs that are significantly different