Table 2.

Associations between TGAb, TPOAb status and extra-thyroid disease in the National Health and Nutrition Examination Survey, 2007 to 2012 stratified by gender, followed up through 2015.

	Patients, No. (%)	Univariate model		Multivariate model
				Model 1		Model 2
		OR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
TGAb
Diabetes	879 (8.89)	1.75 (1.19-2.55)	<0.01	1.64 (1.08-2.50)	0.02	1.93 (1.21-3.08)	<0.01
Hypertension	2625 (30.73)	0.99 (0.76-1.28)	0.91	0.67 (0.49-0.91)	0.01	0.62 (0.44-0.88)	0.01
Cardiovascular disease	787 (8.07)	1.38 (0.84-2.27)	0.20	1.01 (0.58-1.77)	0.97	1.07 (0.60-1.92)	0.82
Chronic lung disease	1325 (17.82)	0.92 (0.60-1.41)	0.69	0.91 (0.58-1.44)	0.69	0.90 (0.57-1.42)	0.63
Arthritis	2101 (24.22)	1.38 (1.03-1.85)	0.03	0.99 (0.74-1.34)	0.97	1.05 (0.76-1.45)	0.76
Cancer	711 (9.37)	1.10 (0.71-1.71)	0.66	0.69 (0.41-1.16)	0.16	0.69 (0.40-1.18)	0.17
CKD stage 3-5	651 (6.01)	1.63 (1.10-2.40)	0.02	0.96 (0.62-1.49)	0.86	0.96 (0.62-1.47)	0.84
TPOAb
Diabetes	879 (8.89)	1.28 (0.90-1.81)	0.17	1.25 (0.86-1.82)	0.24	1.37 (0.91-2.07)	0.13
Hypertension	2625 (30.73)	1.13 (0.88-1.45)	0.33	0.86 (0.65-1.14)	0.28	0.84 (0.64-1.11)	0.22
Cardiovascular disease	787 (8.07)	1.42 (0.91-2.24)	0.12	1.18 (0.74-1.88)	0.48	1.25 (0.74-2.11)	0.39
Chronic lung disease	1325 (17.82)	0.76 (0.57-1.02)	0.07	0.71 (0.54-0.95)	0.02	0.71 (0.53-0.95)	0.02
Arthritis	2101 (24.22)	1.28 (0.99-1.66)	0.06	0.98 (0.71-1.35)	0.90	1.04 (0.76-1.44)	0.77
Cancer	711 (9.37)	0.95 (0.64-1.40)	0.79	0.66 (0.42-1.03)	0.07	0.66 (0.41-1.06)	0.08
CKD stage 3-5	651 (6.01)	1.35 (0.94-1.95)	0.11	0.96 (0.66-1.39)	0.82	0.91 (0.61-1.36)	0.65

Model 1: adjusted for age, sex, race, poverty index, education, smoking, BMI and TSH.

Model 2: adjusted for age, sex, race, poverty index, education, smoking, BMI, diabetes, hypertension, CVD, chronic lung disease, arthritis, cancer, TSH, eGFR.