Table 4.
Associations between different TGAb, TPOAb status and heart disease mortality in the National Health and Nutrition Examination Survey, 2007 to 2012 followed up through 2019.
| Characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR | p | HR | p | |
| Age | 1.13 (1.11-1.15) | <0.01 | 1.11 (1.08-1.13) | <0.01 |
| Gender | ||||
| Male | 1 | / | 1 | / |
| Female | 0.71 (0.55-0.92) | 0.01 | 0.46 (0.32-0.66) | <0.01 |
| Race | ||||
| Mexican American | 1 | / | 1 | / |
| Non-Hispanic White | 2.82 (1.34-5.93) | <0.01 | 1.40 (0.67-2.96) | 0.36 |
| Non-Hispanic Black | 2.57 (1.23-5.37) | 0.01 | 1.52 (0.74-3.12) | 0.25 |
| Other | 1.11 (0.45-2.75) | 0.82 | 0.90 (0.37-2.19) | 0.81 |
| Education status | ||||
| Under high school | 1 | / | 1 | / |
| High school or equivalent | 0.71 (0.46-1.08) | 0.11 | 1.03 (0.64-1.66) | 0.90 |
| Above high school | 0.27 (0.20-0.38) | <0.01 | 0.59 (0.42-0.82) | <0.01 |
| Poverty rartio | ||||
| ≤1 | 1 | / | 1 | / |
| 1<to ≤ 3 | 1.87 (1.22-2.87) | <0.01 | 1.10 (0.70-1.71) | 0.68 |
| >3 | 0.63 (0.38-1.03) | 0.07 | 0.65 (0.38-1.12) | 0.12 |
| TSH | ||||
| 0.34<to<5.6 | 1 | / | 1 | / |
| ≤0.34 | 2.39 (0.89-6.38) | 0.08 | 1.37 (0.47-4.01) | 0.56 |
| ≥5.6 | 1.93 (0.73-5.11) | 0.18 | 1.01 (0.37-2.76) | 0.98 |
| Smoking | ||||
| Never | 1 | / | 1 | / |
| Ever | 2.08 (1.54-2.79) | <0.01 | 0.90 (0.66-1.23) | 0.51 |
| Current | 1.23 (0.75-2.01) | 0.41 | 1.91 (1.22-2.98) | 0.01 |
| BMI | ||||
| 18.5≤BMI<25 | 1 | / | 1 | / |
| BMI<18.5 | 0.35 (0.07-1.65) | 0.18 | 0.37 (0.08-1.75) | 0.20 |
| BMI≥25 | 1.18 (0.77-1.81) | 0.44 | 0.87 (0.57-1.35) | 0.54 |
| Diabetes | 4.78 (3.14-7.28) | <0.01 | 1.81 (1.20-2.73) | <0.01 |
| Hypertension | 5.33 (3.69-7.70) | <0.01 | 1.34 (0.85-2.11) | 0.20 |
| Cardiovascular disease | 11.13 (7.70-16.08) | <0.01 | 2.40 (1.63-3.54) | <0.01 |
| Chronic lung disease | 1.57 (1.00-2.45) | 0.05 | 1.30 (0.81-2.07) | 0.27 |
| Arthritis | 4.86 (3.46-6.84) | <0.01 | 1.41 (0.93-2.15) | 0.11 |
| Cancer | 2.12 (1.36-3.32) | <0.01 | 0.57 (0.32-1.01) | 0.06 |
| eGFR<60 | 11.21 (7.87-15.96) | <0.01 | 1.53 (1.06-2.20) | <0.01 |
| TGAb | 2.46 (1.40-4.33) | <0.01 | 1.92 (1.04-3.56) | 0.08 |
| TPOAb | 1.49 (0.94-2.35) | 0.09 | 0.93 (0.56-1.52) | 0.75 |
*Multivariate analysis adjusted for age, sex, race, poverty index, education, smoking, BMI, diabetes, hypertension, CVD, chronic lung disease, arthritis, cancer, TSH, eGFR, TgAb and TPOAb.