Table 4.
GRADE assessments for ferric carboxymaltose compared to iron sorbitol for anemia in Indians.
| FCM compared to Iron Sorbitol for Anaemia in Indians | |||||
|
Patient or population: Anaemic Indians Setting: Hospital Intervention: FCM Comparison: Iron Sorbitol | |||||
| Outcomes |
No of participants
(studies) Follow-up |
Certainty of the evidence
(GRADE) |
Relative effect
(95% CI) |
Anticipated absolute effects | |
| Risk with Iron Sorbitol | Risk difference with FCM | ||||
| Hb (g/dL)(Change scores) – 2 Weeks | 100 (1 RCT) |
⨁⨁◯◯ Lowa,b |
– | The mean hb (g/dL)(Change scores)—2 Weeks was0 | MD1.03 higher (0.91 higher to 1.15 higher) |
| Hb (g/dL)(Change scores)—6 Weeks | 100 (1 RCT) |
⨁⨁◯◯ Lowa,b |
– | The mean hb (g/dL)(Change scores)—6 Weeks was0 | MD1.94 higher (1.72 higher to 2.16 higher) |
| Serum Ferritin (μg/l)(Change scores) – 2 Weeks | 100 (1 RCT) |
⨁⨁◯◯ Lowa,b |
– | The mean serum Ferritin (μg/l)(Change scores)—2 Weeks was0 | MD11.75 higher (9.52 higher to 13.98 higher) |
| Serum Ferritin (μg/l)(Change scores) – 6 weeks | 100 (1 RCT) |
⨁⨁◯◯ Lowa,b |
– | The mean serum Ferritin (μg/l)(Change scores)—6 weeks was0 | MD44.21 higher (39.48 higher to 48.94 higher) |
| Adverse Events | 100 (1 RCT) |
⨁⨁◯◯ Lowa,b |
RR 0.22 (0.11 to 0.45) |
640 per 1,000 |
499 fewer per 1,000 (570 fewer to 352 fewer) |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and therelative effect of the intervention (and its 95% CI). CI: confidence interval;MD: mean difference;RR: risk ratio | |||||
|
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | |||||
|
Explanations a. Downgraded by one for limitation in study design (High RoB) b. Downgraded by one for imprecision (small sample size) | |||||