Table 4.
Independent variable | Favorable outcomes | Spin present | Discrepancy between protocol and reported outcomes | Retrospective registration |
---|---|---|---|---|
Commercial sponsorship (SE) | -0.095 (0.60)a | 0.33 (0.7379)a | -1.47 (0.86)a | -0.49 (1.03)a |
OR (95% CI) | 0.91 (0.28, 3.02) | 1.39 (0.32, 6.00) | 0.23 (0.04, 1.18) | 0.62 (0.08, 5.63) |
Composite outcome (SE) | 0.49 (0.67)a | 0.71 (0.75)a | 1.45 (0.92)a | 1.50 (0.97)a |
OR (95% CI) | 2.02 (0.45, 9.12) | 2.02 (0.45, 9.12) | 4.27 (0.72, 28.91) | 4.50 (0.73, 37.66) |
Sample size (SE) | 0.00062 (0.00060)a | -0.0018 (0.0013)a | -0.00022 (0.00061)a | -0.00045 (0.00074)a |
OR (95% CI) | 1.00 (1.00, 1.00) | 1.00 (1.00, 1.00) | 1.00 (1.00, 1.00) | 1.00 (1.00, 1.00) |
LTFU (SE) | -0.030 (0.040)a | 0.085 (0.090)a | -20.93 (15091.4)a | 0.0028 (0.035)a |
OR (95% CI) | 0.97 (0.88, 1.04) | 1.09 (0.98, 1.41) | 0 (0, ∞) | 1.00 (0.92, 1.08) |
Year of publication (SE) | 0.078 (0.048)a | -0.050 (0.052)a | 0.032 (0.082)a | -0.079 (0.099)a |
OR (95% CI) | 1.08 (0.99, 1.20) | 0.95 (0.85, 1.05) | 1.03 (0.87, 1.22) | 0.92 (0.76, 1.12) |
Multicenter trial (SE) | -0.98 (0.62)a | -0.81 (0.89)a | -0.22 (0.96)a | -0.69 (0.83)a |
OR (95% CI) | 0.38 (0.11, 1.16) | 0.44 (0.06, 2.27) | 0.80 (0.10, 4.85) | 0.50 (0.09, 2.61) |
Duration of follow-up (SE) | 0.00016 (0.00044)a | -0.00035(0.0019)a | 0.0014 (0.0020)a | 0.00065 (0.00068)a |
OR (95% CI) | 1.00 (1.00, 1.00) | 1.00 (1.00, 1.00) | 1.00 (1.00, 1.01) | 1.00 (1.00, 1.00) |
Primary LMWH (SE) | 0.37 (1.2)a | 1.15 (1.49)a | 0.22 (1.31)a | 0.24 (1.32)a |
OR (95% CI) | 1.44 (0.16, 30.81) | 3.17 (0.11, 88.86) | 1.25 (0.05, 15.66) | 1.27 (0.10, 30.47) |
Use of ITT (SE) | -0.33 (0.59)a | 1.07 (0.75)a | -1.57 (0.93)a | 0.14 (0.74)a |
OR (95% CI) | 0.72 (0.22, 2.32) | 2.91 (0.67, 13.49) | 0.21 (0.03, 1.13) | 1.15 (0.27, 5.07) |
ITT, intention-to-treat; LMWH, low-molecular-weight heparin; LTFU, loss to follow-up; OR, odds ratio.
Nonsignificant P > .05.