Figure 7.

CaLac treatment restores PDH activity and rescues OCR in TAZ-KO cells. Phosphorylated PDH (p-PDH) levels were measured by WB following treatment with calcium lactate (CaLac) at the indicated concentrations (A) and with 10 mM CaLac (B). Oxygen consumption rates (OCR) of myoblasts subjected to 2.5 mM CaLac (C) and 12.5 mM CaLac (D) treatments. n = 5. Data points represent mean ±S.D. (error bars) for each individual biological replicate of each group. ∗ 0.01<p < 0.05, ∗∗ 0.001<p < 0.01, ∗∗∗ <p < 0.001.