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hGCN5 domain structure. The domains of GCN5 are aa 1 to 110 (nonessential function) (14), aa 110 to 251 (the HAT domain) (16), aa 251 to 338 (the ADA2 interaction domain) (14), and aa 338 to 427 (the BrD motif) (53). Sequences within the BrD are aa 339 to 363 (the proline-rich sequence [hBrD.Pro]) and aa 364 to 421 (the helix-turn-helix-turn motif [hBrD.HT]). The prolines and helix-turn-helix-turn region are shown in boldface.
