Table 3.

Stimulus-responsive peptide-based DDSs for cancer treatment.

Stimuli-responsive peptides	Cargo	Targeted Tumor	Stimuli	Ref
YSA	HCPT	Human bladder metastatic cell carcinoma cells T24	CTSB	[141]
CAP	DOX	Human prostate cancer cells PC-3 and CAFs	FAP-α	[142]
MRP	PFD GEM	Pancreatic stellate cells (PSCs) Human pancreatic cancer cell line Mia-paca-2	MMP-2	[143]
GFFpY	LND	Human breast cancer cells HeLa	ALP	[144]
SPL	Prednisolone	Human colon adenocarcinoma cells LS 174T and Caco-2	pH	[148]
PEG-b-PLL/DMMA	PTX	Human breast cancer adriamycin-resistant cell line MCF-7/ADR	pH	[149]
Lan-PdNPs@GSH	DOX	Cervical cancer cells U14	Ph and laser	[150]
PTP-7	PTX	MCF-7, HCT116, 4T1	pH and Enzyme	[151]
OE	GEM PTX	Mouse breast cancer cells 4T1	Ph	[153]
KKFKFEFEF	MTX	Mouse breast cancer cells 4T1	Ph	[154]
SynB1-ELP	DOX PTX	Human breast adenocarcinoma cells MDA-MB 321	temperature	[158,159]
RGD-ELP	DTX	Human breast adenocarcinoma cells MDA-MB 321	temperature	[160]
mPEG-b-PDTG	NR	Melanoma cells B16F10	ROS	[163]
Met-PEA-PEG	NR GA	Human Prostate cancer cells PC-3 Human cervical cancer cells HeLa	ROS	[164]
CPPT	Cur DOX	Human lung cancer cells A549	pH Reduction ROS	[166]
cRGD-rPTM	DOX	Human breast adenocarcinoma Cells MDA-MB 321	Reduction	[167]
PLA-b-PEG-b-pHis	DOX	Mammary tumor cell line MCF-7	pH	[171]
PE-pHis-PE-p(NIPAM)-FA-PC	DOX	Human oral epidermal-like carcinoma cells KB	pH and temperature	[172]
FA-PEG-b-PPLG	DOX	Folic acid high expression cancer cells KB	pH	[173]
PEG-b-PPLG NCA	DOX	Triple-negative breast cancer cell line MDA-MB-468	pH	[174]
PGlu	Antiangiogenic DNA	Mouse colon cancer cell CT26	pH	[175]
mPEsG-b-PEG-b-PLL/DOCA	DOX PTX	Human lung adenocarcinoma cells A549	pH	[176]
ELP (CP)	DOX	Mouse colon cancer cells C26	temperature	[177]
PEG-PLL/DMMA	Indocyanine Green (IGG)	Human cervical cancer cells HeLa	pH and Reduction	[178]
PEG114-b-PLL25/DMMA	DOX	Human lung adenocarcinoma cells A549	Reduction	[179]
PEG-PBnSec	DOX	Human cervical cancer cells HeLa	ROS	[180]