Table 2.
Vancomycin Hepatotoxicity: 9 cases Laboratory Test Results
| Feature | Initial | Peak | ||
|---|---|---|---|---|
| Mean | Range | Mean | Range | |
| ALT (U/L) | 292 | 51–2018 | 820 | 117–2018 |
| AST (U/L) | 255 | 73–1232 | 644 | 73–1494 |
| Alk P (U/L) | 302 | 61–597 | 395 | 265–968 |
| Total Bilirubin (mg/dL) | 1.0 | 0.4–14.1 | 3.3 | 0.9–19.4 |
| INR | 1.1 | 1.1–1.6 | 1.6 | 1.1–5.4 |
| R ratio | 1.6 | 1.1–5.4 | ||
| Creatinine (mg/dL) | 1.3 | 0.7–8.9 | 2.5 | 0.6–9.8 |
| Hemoglobin (g/dL) | 10.5 | 8.4–12.6 | ||
| White cell count (/μL) | 8.6 | 1.8–13.3 | ||
| Eosinophil count (/μL) | 208 | 70.2–1734 | 952 | 0.6–9.8 |
| Platelet count (/μL) | 181 | 116–450 | ||
| Number | Percent | |||
| Enzyme Pattern | ||||
| Hepatocellular (R ≥ 5) | 2 | 22% | ||
| Mixed (R > 2 <5) | 3 | 33% | ||
| Cholestatic (R ≤ 2) | 4 | 44% | ||
| ANA Positive | 1 | 11% | ||
| SMA Positive | 1 | 11% | ||
| HLA A*32:01 | 7 | 78% | ||
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; Alk, alkaline phosphatase; R = (ALT/ULN ÷ Alk P/ULN); ANA, anti-nuclear antibody; SMA, smooth muscle antibody; HLA, human leukocyte antigen.