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. 2024 Feb 22;16(1):2315631. doi: 10.1080/19490976.2024.2315631

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — The dysbiosis upon PD-1 blockade is improved upon supplementation with CBM588. LEfSe analysis at several taxonomic level revealed enrichment of multiple bacterial taxa in isotype control or anti-PD-1-treated mice when compared to those who received the combination of treatment. (a) Data are shown as log10 LDA score on each bacterial taxa of which relative abundance is enriched in group a (blue) vs group B (red). (B-D) LEfSe cladograms of differentially abundant bacterial taxa based on pairwise analysis. (b) isotype control vs anti-PD-1. (c) isotype control vs combo. (d) anti-PD-1 vs combo.