Table 2.
Clinical trials demonstrating the impact of blood transfusion on clinical outcomes
| Trials | Study population | Conclusion |
|---|---|---|
|
Smilowitz N.R. et al. [14] Retrospective cohort study |
3,050 patients underwent orthopedic surgery | Blood transfusion was associated with increased mortality. |
|
Glance L.G. et al. [15] Retrospective study |
10,100 patients undergoing general, vascular or orthopedic surgery | Intraoperative RBC transfusion was associated with increased risk of mortality and morbidity (septic, thromboembolic complications, etc.) |
|
Bernard A.C. et al. [16] Prospective systematic study |
125,223 general surgery patients in 121 hospitals as part of the ACS-NSQIP (The American College of Surgeons National Surgical Quality Improvement Program) | Intraoperative blood transfusion (even one unit of packed RBC) was associated with increased risk of mortality and morbidity in general surgery patients. |
|
Woldendorp K, et al. [17] Meta-analysis of thirty-nine studies |
Thirty-nine studies with 180,074 patients after cardiac surgery | Perioperative red blood transfusion appeared to be associated with a significant reduction in long-term survival for patients after cardiac surgery. |
|
Li Y et al. [18] Retrospective study |
6,752 patients who underwent cardiac surgery | Blood transfusion was associated with worse outcomes in cardiac surgery patients |
|
Dae won Park et al. [19] Propensity-matched analysis of a prospective observational database |
1,054 patients severe sepsis and septic shock. |
Red blood cell transfusions were associated with lower risk of mortality |
|
Suk Yong Jang et al. [20] Nationwide Cohort Study |
10,973 patients in the transfusion group and 3,771 patients in the non transfusion group |
Transfusion group did not show significantly worse results than the non-transfusion group |
| Wen-Chih Wuet al [21] retrospective study | Patients with acute myocardial infarction, 65 years and older | Blood transfusion is associated with a lower short-term mortality rate |
|
Yi Zheng et al. [22] a systematic review and meta-analysis |
28,797 patients in intensive care unit | RBC transfusion does not increase the risk of in-hospital mortality |