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. 2024 Feb 23;19:15. doi: 10.1186/s13062-024-00459-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Upregulated genes in lenvatinib-treated HCC cells identified by RNA-seq analysis. (A) IC50 value of lenvatinib for HuH7 cells determined by CCK-8 assay. Each point on the dose–response curves represent three technical replicates. (B) Volcano map showing mRNAs upregulated (red) and downregulated (green) in the lenvatinib-treated group relative to the control group. (C) Top 20 enriched KEGG pathways in lenvatinib treated HCC cells. (D) Five new upregulated genes were verified by RT-qPCR analysis. (E) Five new upregulated genes were verified by western blot. *P < 0.05, **P < 0.01, ***P < 0.001