Table 2.
Frequency of mutations associated with resistance to RIF (in the rpoB gene) and isoniazid (Ser315Thr in the katG gene and position −15 in the promoter of the inhA gene) in MDR-TB strains.
| RIF-R N. (%) |
Leu452Pro | Ser450Leu | Asp435Val | Gln432Pro | Leu430Pro | His445Tyr | Asp435Tyr | Total | |
|---|---|---|---|---|---|---|---|---|---|
| N. (%) | |||||||||
|
INH-R
N. (%) |
Ser315Thr | 1 (2.22) | 21 (46.7) | 5 (11.1) | 2 (4.42) | 1 (2.22) | 1 (2.22) | 3 (6.7) | 34 (75.56) |
| inhA-prom −15 | 1 (2.22) | 1 (2.22) | |||||||
| Ser315Thr + inhA prom | 8 (17.8) | 2 (4.44) | 10 (22.2) | ||||||
| Total N. (%) | 1 (2.22) | 30 (66.7) | 5 (11.1) | 2 (4.42) | 1 (2.22) | 3 (6.7) | 3 (6.7) | 45 (100) | |