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Distribution of the most frequent mutations in rpoB associated with resistance to rifampicin in relation to the level of resistance.
| Level of Resistance | |||||
|---|---|---|---|---|---|
| rpoB Mutation N. (%) | RIF-R | MDR | Pre-XDR | XDR | Total N. (%) |
| Leu452Pro | 1 (2) | 1 (2) | |||
| Ser450Leu | 2 (4) | 24 (48) | 5 (10) | 1 (2) | 32 (64) |
| Asp435Val | 2 (4) | 3 (6) | 5 (10) | ||
| Gln432Pro | 2 (4) | 2 (4) | |||
| Leu430Pro | 1 (2) | 1 (2) | 2 (4) | ||
| His445Tyr | 1 (2) | 3 (6) | 4 (8) | ||
| Asp435Tyr | 3 (6) | 3 (6) | |||
| His445Asp | 1 (2) | 1 (2) | |||
| Total N. (%) | 5 (10) | 35 (70) | 9 (18) | 1 (2) | 50 (100) |
