Table 1.
Characteristics of the study population. The data have been expressed as “n” (%) if they are categorical and as median (interquartile range) or mean (standard deviation) if they are quantitative.
| n = 13 | ||
|---|---|---|
| Age [years, m (SD)] | 42 (13.8) | |
| Gender [n (%)] | Female | 7 (53.8) |
| Male | 6 (46.2) | |
| Comorbidities [n (%)] | Hypertension | 3 (23.1) |
| Obesity | 1 (7.7) | |
| Cardiac | 1 (7.7) | |
| Inmunosuppression | 2 (15.4) | |
| Peripheral Vascular Disease | 1 (7.7) | |
| APACHE II [m (SD)] | 29 (15) | |
| SOFA [m (SD)] | 17 ± 5.7 | |
| Infection source [n (%)] | Respiratory | 8 (61.5) |
| SSTIs | 4 (30.8) | |
| PID | 1 (7.7) | |
| Source control [n (%)] | Thorax Drainage | 4 (30.8) |
| Surgery | 3 (23.1) | |
| Coinfection [n (%)] | FLUB-V | 5 (38.5) |
| Metapneumovirus | 2 (15.4) | |
| Microbiologic culture-positive tests | Isolated PBC [n (%)] | 5 (38.5) |
| PBC + BAL [n (%)] | 2 (15.4) | |
| Bronchoalveolar lavage [n (%)] | 4 (31) | |
| Skin/soft tissue [n (%)] | 1 (7.7) | |
| PBC + Ascitic fluid [n (%)] |
1 (7.7) | |
| Septic Shock [n (%)] | 13 (100) | |
| Septic Cardiomyopathy [n (%)] | 10 (76.9) | |
| Cardiovascular SOFA [m (SD) ] | 4 (0.6) | |
| Dobutamine use [n (%)] | 10 (76.9) | |
| Hydrocortisone [n (%)] | 13 (100) | |
| IMV [n (%)] | 9 (69.2) | |
| ECMO (VA. VV) [n (%)] | Total [n(%)] | 7 (53.8) |
| VA [n(%)] Low perfusion phenotype |
5 (38.4) | |
| CRRT [n (%)] | 10 (76.9) | |
| HA [n (%)] | (total) | 10 (76.9) |
| Cytosorb® | 9 (69.2) | |
| Toraymixin® | 6 (46.2) | |
| Oxiris® | 2 (15.4) | |
|
Sequential hemoadsorption [n (%)] |
Cytosorb® + Toraymixin® | 6 (46.2) |
| Low IgG [n (%)] | 9 (69.2) | |
|
Cytokine HA duration [hours, m (SD)] |
50 (34) | |
|
Length of ICU stay [days, m (SD)] |
33 (40) | |
|
Length of hospital stay [days, m (SD)] |
54.85 (42) | |
| ICU mortality [n (%)] | 3 (23.1%) | |
| In hospital mortality [n (%)] | 3 (23.1%) |
APACHE—Acute Physiology And Chronic Health Evaluation; BAL—Bronchoalveolar lavage; CRRT—continuous renal replacement therapy; ECMO—extracorporeal membrane oxygenation (VA—venoarterial, VV—venovenous); FLUB-V—Influenza-B virus; HA—hemoadsorption; ICU—intensive care unit; IMV—invasive mechanical ventilation; m—mean; n—number of population; PBC—peripheral blood culture; PID—Pelvic Inflammatory Disease; SD—standard deviation; SOFA—sequential organ failure assessment; SSTIs—Skin and Soft Tissue Infections.