Table 3.

Distinguishing between phenotypes in patients with severe septic shock due, based on identifiable treatable traits.

Precision Medicine Strategies		Target (s)	Clinical Application
Hyperinflammatory profile	High endotoxinemia	Endotoxinemia	Rescue therapy Hemoadsorption
	Severe hypercytokinemia	Cytokine levels
	Sequential hemoadsorption	Endotoxin and cytokine hemoadsorption
Low perfusion phenotype	Patients with septic cardiomyopathy		ECMO venoarterial
Low immunoglobulin phenotype	Sepsis-associated hypogammaglobulinemia250 mg/kg/d by a 10 h infusion for 3 consecutive days