Table 2.

Pearson correlation coefficients, along with related p-values and false discovery rate (FDR)-corrected p-values elucidating the connections between sequence and structure distances for the closed, open, and complex forms with ACE2 of the XBB variants spike protein. The significance was assessed by using the FDR p-value correction for multiple testing. A corrected p-value lower than 0.01 was considered significant.

Spike Structure	Pearson Coefficient	FDR Corrected p-Value
Closed	0.462	0.042
Open	0.447	0.042
Complex	0.447	0.042