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. 2024 Feb 2;12(2):356. doi: 10.3390/biomedicines12020356

Table 6.

Intermediate CAG repeat expansion in ATXN2 gene associated with ALS extracted from 12 studies with statistical determinations.

Study CAG Repeat Number p-Value a Odds Ratio b
North America [15] 27–33 0.000036 2.8 [1.54–5.12]
Europe [22] >30 0.0062 -
France and Canada [39] ≥29 0.00024 5.5 [1.9–15.9]
Europe [40] >30 0.004 5.74 [4.26–7.22]
Flanders [23] 27–33 0.012 -
South Italy [41] ≥28 0.001 5.832 [1.71–9.78]
Turkey [25] >30 0.01721 -
Meta-analysis [24] 29–33 - >1
Europe and North America [26] 30–33 0.0001 4.44 [2.91–6.76]
Sardinia [27] ≥31 0.0001 -
Brazil [42] ≥26 0.005 2.56 [1.29–5.08]
Europe [32] ≥31 9.50 × 10−7 6.93 [3.19–15.02]
Spain (present study) ≥27 0.0013 2.666 [1.471–4.882]

Statistical determinations include p-value and odds ratio (if present). a Fisher’s test, b 95% confidence interval.