Table 3.
Determined molecular characteristics of BC cell lines. Signal intensity indicated by +, ++, and +++ for ER, PR, AR, and HER2 protein as determined by densitometric analysis of immunoblots and in relation to signals of BT-474 (Figure S1). TNBC status is defined by absence of ER and PR and a weak (+) or absent HER2 signal. Assignment of cell lines to cluster and PAM50 subtype is based on unsupervised clustering analysis presented in Figure 1.
| Cell Line | ER | PR | AR | HER2 | TNBC | Cluster | PAM50 Subtype |
|---|---|---|---|---|---|---|---|
| BT-474 | ++ | ++ | ++ | +++ | A | luminal | |
| CAL-120 | yes | B | basal-like | ||||
| CAL-148 | + | + | yes | A | luminal | ||
| CAL-51 | + | yes | B | basal-like | |||
| CAL-85-1 | + | yes | B | basal-like | |||
| COLO-824 | + | yes | B | basal-like | |||
| DU-4475 | yes | B | luminal | ||||
| EFM-19 | +++ | ++ | ++ | ++ | A | luminal | |
| EFM-192A | + | +++ | A | luminal | |||
| EFM-192B | + | +++ | A | luminal | |||
| EFM-192C | ++ | + | + | +++ | A | luminal | |
| ETCC-006 | yes | B | basal-like | ||||
| ETCC-007 | + | yes | B | luminal | |||
| EVSA-T | ++ | A | luminal | ||||
| HCC-1143 | + | yes | B | basal-like | |||
| HCC-1599 | + | yes | B | basal-like | |||
| HCC-1937 | + | yes | B | basal-like | |||
| HDQ-P1 | + | yes | B | luminal | |||
| HS-578T | yes | B | luminal | ||||
| IPH-926 | ++ | A | luminal | ||||
| JIMT-1 | ++ | B | luminal | ||||
| KPL-1 | +++ | +++ | + | A | luminal | ||
| MCF-7 | +++ | + | A | luminal | |||
| MDA-MB-231 | yes | B | basal-like | ||||
| MDA-MB-453 | +++ | ++ | A | luminal | |||
| MDA-MB-468 | yes | B | basal-like | ||||
| MFM-223 | +++ | yes | A | luminal | |||
| SK-BR-3 | ++ | A | luminal | ||||
| T-47D | +++ | +++ | ++ | ++ | A | luminal |