Table 3.
Primary and secondary outcomes of patients according to their neutrophil/lymphocyte ratio levels *.
| Variables | Quartile #1 (n = 1010) | Quartile #2 (n = 1010) | Quartile #3 (n = 1009) | Quartile #4 (n = 1010) | Univariable Analysis | Multivariable Analysis ** | ||
|---|---|---|---|---|---|---|---|---|
| p Value | Odds Ratio (95% CI) | p Value | ||||||
| Hospital mortality, no. (%) | 24 (2.4) | 27 (2.7) | 34 (3.4) | 43 (4.3) | 0.075 | Q#2 | 1.09 (0.62, 1.93) | 0.763 |
| Q#3 | 1.3 (0.76, 2.23) | 0.343 | ||||||
| Q#4 | 1.28 (0.76, 2.16) | 0.352 | ||||||
| Mortality at 6 months, no. (%) | 162 (16) | 144 (14.3) | 152 (15.1) | 180 (17.8) | 0.147 | Q#2 | 0.83 (0.64, 1.07) | 0.149 |
| Q#3 | 0.84 (0.66, 1.08) | 0.185 | ||||||
| Q#4 | 0.86 (0.68, 1.1) | 0.238 | ||||||
| Need for invasive mechanical ventilation, no. (%) | 152 (15) | 165 (16.3) | 185 (18.3) | 202 (20) | 0.018 | Q#2 | 1.07 (0.84, 1.37) | 0.581 |
| Q#3 | 1.19 (0.93, 1.51) | 0.164 | ||||||
| Q#4 | 1.12 (0.88, 1.43) | 0.341 | ||||||
| Need for invasive and non-invasive mechanical ventilation, no. (%) | 300 (29.7) | 324 (32.1) | 346 (34.3) | 378 (37.4) | 0.002 | Q#2 | 1.08 (0.89, 1.32) | 0.422 |
| Q#3 | 1.15 (0.95, 1.4) | 0.158 | ||||||
| Q#4 | 1.12 (0.92, 1.37) | 0.254 | ||||||
| ICU admission | 319 (31.6) | 363 (35.9) | 405 (40.1) | 492 (48.7) | <0.001 | Q#2 | 1.19 (0.97, 1.46) | 0.090 |
| Q#3 | 1.38 (1.13, 1.69) | 0.002 | ||||||
| Q#4 | 1.64 (1.34, 2.01) | <0.001 | ||||||
| p value | Estimate (95% CI) | p value | ||||||
| Hospital-free days, median (IQR) | 24.3 (22.06, 25.88) | 24.01 (21.12, 25.48) | 23.98 (21, 25.41) | 23.55 (19.96, 25.23) | <0.001 | Q#2 | −0.41 (−0.93, 0.11) | 0.120 |
| Q#3 | −0.43 (−0.95, 0.09) | 0.104 | ||||||
| Q#4 | −0.63 (−1.15, −0.11) | 0.017 | ||||||
CI: confidence interval, ICU: intensive care unit, IQR: interquartile range, Q: quartile. * Neutrophil-lymphocyte ratio levels per quartiles: Quartile #1, <5.13; Quartile #2, ≥5.13 and <9.26; Quartile #3, ≥9.26 and <16.35; Quartile #4, ≥16.35. ** Data were analyzed using multivariable regression models adjusting for pneumonia severity index. Quartile #1 was the reference.