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The role of ABC transporter in topo-active cancer drug resistance. Organic anion transporting polypeptide (OATP) transporters for the influx of topo-active drugs. ATP-binding cassette (ABC) efflux transporters such as P-gp are overexpressed in cancer cells and contribute to multidrug resistance (MDR) against topo-active drugs. P-glycoprotein (P-gp).
